Practice exercise (made-up values, not clinical guidance). A patient who weighs 78 kg needs a loading dose of tobramycin to reach a level of 8 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 2.5 h later?
Practice exercise (made-up values, not clinical guidance). A 61 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 12 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 750 mL/min. What infusion rate R in mg/min keeps the steady-state level at 3 mg/L?
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 42 mg/h with no loading dose. The patient's clearance is 3.5 L/h and the half-life is 8 h. What is the level C after 21 h?
Practice exercise (made-up values, not clinical guidance). A 58 kg patient takes oral theophylline (F = 1) every 8 h. The clearance is 0.05 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
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