Clinical pharmacokinetics worksheet with answers

Free printable Clinical pharmacokinetics worksheet: 6 problems from easy to exam level, with an answer key. Print it or save it as a PDF.

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1.Easy
Vd = 0.5 L/kgC = 10 mg/LLD = ?89 kg

Practice exercise (made-up values, not clinical guidance). A patient who weighs 89 kg needs a loading dose of theophylline to reach a level of 10 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.

89 kgVd = 0.5 L/kgC = 10 mg/L
LD = mg
2.Easy
Vd = 0.3 L/kgC = 10 mg/LLD = ?52 kg

Practice exercise (made-up values, not clinical guidance). A patient who weighs 52 kg needs a loading dose of tobramycin to reach a level of 10 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.

52 kgVd = 0.3 L/kgC = 10 mg/L
LD = mg
3.Medium
110100t (h)C (mg/L)C₀ = 9 mg/Lt½ = 2.5 hC₀/2

Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 200 mg of tobramycin. The level back-extrapolated to time zero is 9 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.

D = 200 mgC₀ = 9 mg/Lt½ = 2.5 h
CL = L/h
4.Medium
110t (h)C (mg/L)C₀ = 6 mg/Lt½ = 3 hC₀/2

Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 140 mg of tobramycin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 3 h. Find the volume of distribution Vd.

D = 140 mgC₀ = 6 mg/Lt½ = 3 h
Vd = L
5.Hard
VCss,avg​ = ?1000 mg · q12hCL = 4 L/hS = 1 · F = 1

Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 4 L/h. Each dose is 1000 mg of vancomycin. Find the average steady-state level Css,avg.

CL = 4 L/hτ = 12 hS = 1F = 1D = 1000 mg
Css,avg = mg/L
6.Hard
t (h)C (mg/L)Css​t = ?75%

Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 6 h. How long t does it take to reach 75% of the steady-state level?

t½ = 6 h75% Css
t = h

Answer key

  1. 1. LD = 445 mg
  2. 2. LD = 156 mg
  3. 3. CL = 6.161 L/h
  4. 4. Vd = 23.33 L
  5. 5. Css,avg = 20.83 mg/L
  6. 6. t = 12 h

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