Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of gentamicin, which has a half-life of 2.5 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of tobramycin in a patient is 0.231 h⁻¹. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 800 mL/min. What infusion rate R in mg/min keeps the steady-state level at 4 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 800 mL/min. What infusion rate R in mg/min keeps the steady-state level at 3 mg/L?
Practice exercise (made-up values, not clinical guidance). A 96 kg patient has a digoxin level of 0.5 mcg/L; the target is 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A 63 kg patient has a phenytoin level of 4.5 mg/L; the target is 15 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
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