Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 8 h. What percentage f of the steady-state level has been reached after 32 h?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 25 mg/L. The half-life is 6 h, and the drug is eliminated by first-order kinetics. What is the level C 19 h later?
Practice exercise (made-up values, not clinical guidance). A 57 kg patient receives a theophylline infusion. The clearance is 0.045 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 12 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 180 mg of gentamicin. The level back-extrapolated to time zero is 9 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 60 kg patient on regular gentamicin doses is at steady state. The target is a peak of 6 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.25 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 10 h. How long t does it take to reach 90% of the steady-state level?
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