Practice exercise (made-up values, not clinical guidance). A patient who weighs 55 kg needs a loading dose of tobramycin to reach a level of 8 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient who weighs 96 kg needs a loading dose of theophylline to reach a level of 12 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 240 mg of gentamicin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 3 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 35 mg/L at 2 h and 17.5 mg/L at 12 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 51-year-old woman weighs 70 kg and has a serum creatinine of 2.8 mg/dL (248 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual gentamicin regimen is 80 mg every 8 h for a creatinine clearance of 120 mL/min. Keeping the dose, the interval is lengthened in proportion to the fall in clearance. Find the new dosing interval τ. Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 3.5 L/h. What dose D in mg gives an average steady-state level of 15 mg/L?
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