Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 10 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 3.5 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 57 kg needs a loading dose of vancomycin to reach a level of 25 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 8 mg/L at 1 h and 1 mg/L at 7 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 25 mg/L at 1 h and 9.3 mg/L at 11 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 6 h. How long t does it take to reach 90% of the steady-state level?
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 4 h. The target is a peak of 6 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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