Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 25 mg/L. The half-life is 8 h, and the drug is eliminated by first-order kinetics. What is the level C 11 h later?
Practice exercise (made-up values, not clinical guidance). In a patient, vancomycin has an elimination half-life of 8 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 210 mg of tobramycin. The level back-extrapolated to time zero is 12 mg/L and the half-life is 2.5 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 160 mg of tobramycin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 3 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A 45-year-old woman weighs 93 kg and has a serum creatinine of 2 mg/dL (177 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual tobramycin regimen is 120 mg every 8 h for a creatinine clearance of 100 mL/min. Keeping the dose, the interval is lengthened in proportion to the fall in clearance. Find the new dosing interval τ. Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 90% of the steady-state level?
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