Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 1.5 h. What percentage f of the steady-state level has been reached after 3.75 h?
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of digoxin in a patient is 0.0144 h⁻¹. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 170 mg of tobramycin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 3 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 35 mg/L at 1 h and 8.8 mg/L at 13 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 61 kg patient has a phenytoin level of 12 mg/L; the target is 20 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A 56 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.05 L/kg/h. Each dose is 450 mg of aminophylline. Find the average steady-state level Css,avg.
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