Practice exercise (made-up values, not clinical guidance). A patient who weighs 66 kg needs a loading dose of theophylline to reach a level of 12 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient who weighs 56 kg needs a loading dose of tobramycin to reach a level of 8 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 40 mg/L at 1 h and 12.6 mg/L at 11 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 260 mg of gentamicin. The level back-extrapolated to time zero is 9 mg/L and the half-life is 3 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 62 kg patient on regular gentamicin doses is at steady state. The target is a peak of 8 mg/L and a trough of 1 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
Practice exercise (made-up values, not clinical guidance). A 71 kg patient has a digoxin level of 0.4 mcg/L; the target is 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
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