Practice exercise (made-up values, not clinical guidance). A patient who weighs 81 kg needs a loading dose of tobramycin to reach a level of 8 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 6 h. What percentage f of the steady-state level has been reached after 15 h?
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 8 mg/L at 1 h and 2 mg/L at 5 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 8 mg/L at 1 h and 3.2 mg/L at 5 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A 62 kg patient has a digoxin level of 0.4 mcg/L; the target is 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 52.5 mg/h with no loading dose. The patient's clearance is 3.5 L/h and the half-life is 9 h. What is the level C after 19 h?
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