Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin as a constant IV infusion without a loading dose. The half-life is 10 h. What percentage f of the steady-state level has been reached after 25 h?
Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 9 h. What percentage f of the steady-state level has been reached after 22.5 h?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 140 mg of tobramycin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 50 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 20 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A 78 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.045 L/kg/h. What dose D in mg gives an average steady-state level of 12 mg/L?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 10 h. How long t does it take to reach 95% of the steady-state level?
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