Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of digoxin, which has a half-life of 36 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). In a patient, vancomycin has an elimination half-life of 6 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 70 mL/min. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A 60 kg patient receives a theophylline infusion. The clearance is 0.045 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). A 52 kg patient on regular gentamicin doses is at steady state. The target is a peak of 7 mg/L and a trough of 1 mg/L, and the volume of distribution is 0.25 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
Practice exercise (made-up values, not clinical guidance). A 53 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.045 L/kg/h. What dose D in mg gives an average steady-state level of 15 mg/L?
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