Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of gentamicin, which has a half-life of 3 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 1.5 h. What percentage f of the steady-state level has been reached after 5.25 h?
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 8 mg/L at 2 h and 2 mg/L at 8 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 35 mg/L at 1 h and 7.2 mg/L at 17 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). An 87 kg patient has a phenytoin level of 9 mg/L; the target is 15 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). An 88 kg patient has a digoxin level of 0.4 mcg/L; the target is 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
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