Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of theophylline, which has a half-life of 9 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). In a patient, lidocaine has an elimination half-life of 2 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 35 mg/L at 1 h and 12.4 mg/L at 13 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). An 83 kg patient receives a theophylline infusion. The clearance is 0.04 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 2.5 h. The target is a peak of 6 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A 74 kg patient has a phenytoin level of 4.5 mg/L; the target is 15 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
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