Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 1 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 58 kg needs a loading dose of gentamicin to reach a level of 10 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 6 mg/L at 2 h and 3 mg/L at 5 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). An 85 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 15 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 9 h. How long t does it take to reach 90% of the steady-state level?
Practice exercise (made-up values, not clinical guidance). An 83 kg patient has a digoxin level of 0.3 mcg/L; the target is 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
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