Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin as a constant IV infusion without a loading dose. The half-life is 12 h. What percentage f of the steady-state level has been reached after 42 h?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 67 kg needs a loading dose of vancomycin to reach a level of 25 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 220 mg of gentamicin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 3.5 L/h. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 37.5 mg/h with no loading dose. The patient's clearance is 2.5 L/h and the half-life is 9 h. What is the level C after 2 h?
Practice exercise (made-up values, not clinical guidance). A 76 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.045 L/kg/h. What dose D in mg gives an average steady-state level of 15 mg/L?
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