Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of theophylline, which has a half-life of 6 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). In a patient, lidocaine has an elimination half-life of 2 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 8 mg/L at 1 h and 2.6 mg/L at 5 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 8 mg/L at 2 h and 1 mg/L at 8 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 3 h. The target is a peak of 10 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 2.5 h. The target is a peak of 6 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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