Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 8 mg/L. The half-life is 2 h, and the drug is eliminated by first-order kinetics. What is the level C 5 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 10 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 9 h later?
Practice exercise (made-up values, not clinical guidance). A 99 kg patient receives a theophylline infusion. The clearance is 0.05 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 12 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 200 mg of tobramycin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 3 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 4 h. The target is a peak of 7 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 9 h. How long t does it take to reach 95% of the steady-state level?
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