Practice exercise (made-up values, not clinical guidance). A patient who weighs 75 kg needs a loading dose of gentamicin to reach a level of 6 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 40 mg/L. The half-life is 10 h, and the drug is eliminated by first-order kinetics. What is the level C 20 h later?
Practice exercise (made-up values, not clinical guidance). A 58 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 15 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). An 81 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 20 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 4.5 L/h. Each dose is 1000 mg of vancomycin. Find the average steady-state level Css,avg.
Practice exercise (made-up values, not clinical guidance). A 61 kg patient on regular tobramycin doses is at steady state. The target is a peak of 6 mg/L and a trough of 1 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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