Practice exercise (made-up values, not clinical guidance). A patient who weighs 74 kg needs a loading dose of vancomycin to reach a level of 30 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient who weighs 71 kg needs a loading dose of theophylline to reach a level of 12 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 6 L/h. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A 62 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 15 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A 73 kg patient on regular tobramycin doses is at steady state. The target is a peak of 8 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.25 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 2 h. The target is a peak of 8 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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