1.Easy
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of tobramycin in a patient is 0.231 h⁻¹. Find the half-life t½.
k = 0.231 h⁻¹
t½ = h
Clinical pharmacokinetics worksheet with answers
2.Easy
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of theophylline in a patient is 0.077 h⁻¹. Find the half-life t½.
k = 0.077 h⁻¹
t½ = h
3.Medium
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 150 mg of tobramycin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
D = 150 mgC₀ = 8 mg/Lt½ = 2 h
CL = L/h
4.Medium
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 120 mg of gentamicin. The level back-extrapolated to time zero is 9 mg/L and the half-life is 3 h. Find the volume of distribution Vd.
D = 120 mgC₀ = 9 mg/Lt½ = 3 h
Vd = L
5.Hard
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 37.5 mg/h with no loading dose. The patient's clearance is 2.5 L/h and the half-life is 8 h. What is the level C after 22 h?
R = 37.5 mg/hCL = 2.5 L/ht½ = 8 ht = 22 h
C = mg/L
6.Hard
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 30 mg/h with no loading dose. The patient's clearance is 2 L/h and the half-life is 6 h. What is the level C after 16 h?
R = 30 mg/hCL = 2 L/ht½ = 6 ht = 16 h
C = mg/L
Answer key
- 1. t½ = 3.001 h
- 2. t½ = 9.002 h
- 3. CL = 6.498 L/h
- 4. Vd = 13.33 L
- 5. C = 12.77 mg/L
- 6. C = 12.64 mg/L
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