Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of vancomycin, which has a half-life of 6 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 1.5 h. What percentage f of the steady-state level has been reached after 2.25 h?
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 7 mg/L at 1 h and 2.8 mg/L at 5 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 8 mg/L at 1 h and 1 mg/L at 7 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 62-year-old man weighs 75 kg and has a serum creatinine of 2.6 mg/dL (230 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual vancomycin regimen is 1000 mg every 12 h for a creatinine clearance of 100 mL/min. Keeping the dose, the interval is lengthened in proportion to the fall in clearance. Find the new dosing interval τ. Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 30 mg/h with no loading dose. The patient's clearance is 2.5 L/h and the half-life is 6 h. What is the level C after 9 h?
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