Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 8 mg/L. The half-life is 2 h, and the drug is eliminated by first-order kinetics. What is the level C 4.5 h later?
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of theophylline in a patient is 0.077 h⁻¹. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 650 mL/min. What infusion rate R in mg/min keeps the steady-state level at 3 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 30 mg/L at 1 h and 11.9 mg/L at 13 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 100 mg/h with no loading dose. The patient's clearance is 4 L/h and the half-life is 8 h. What is the level C after 14 h?
Practice exercise (made-up values, not clinical guidance). A 55 kg patient has a phenytoin level of 4.5 mg/L; the target is 15 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
Full step-by-step solutions: practise this topic on examproblems.com.