Practice exercise (made-up values, not clinical guidance). A patient who weighs 54 kg needs a loading dose of vancomycin to reach a level of 30 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 3 h later?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 290 mg of gentamicin. The level back-extrapolated to time zero is 12 mg/L and the half-life is 3.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 52 kg patient is to receive an aminophylline infusion (salt factor S = 0.8: 80% of aminophylline is theophylline). The theophylline clearance is 0.04 L/kg/h. What aminophylline infusion rate R in mg/h gives a steady-state theophylline level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 5 L/h. What dose D in mg gives an average steady-state level of 20 mg/L?
Practice exercise (made-up values, not clinical guidance). A 51 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.04 L/kg/h. What dose D in mg gives an average steady-state level of 12 mg/L?
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