Practice exercise (made-up values, not clinical guidance). A patient who weighs 59 kg needs a loading dose of theophylline to reach a level of 12 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 6 h. What percentage f of the steady-state level has been reached after 9 h?
Practice exercise (made-up values, not clinical guidance). A 64 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A 52 kg patient is to be loaded with digoxin tablets to reach a level of 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A 99 kg patient has a theophylline level of 4 mg/L; the target is 10 mg/L. The drug is given intravenously as aminophylline (S = 0.8), and the volume of distribution is 0.5 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A 92 kg patient has a digoxin level of 0.6 mcg/L; the target is 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
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