Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 10 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 5 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 10 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 7.5 h later?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 210 mg of gentamicin. The level back-extrapolated to time zero is 9 mg/L and the half-life is 3.5 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 230 mg of gentamicin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 95% of the steady-state level?
Practice exercise (made-up values, not clinical guidance). A 51-year-old woman weighs 93 kg and has a serum creatinine of 1.4 mg/dL (124 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual levetiracetam dose is 1000 mg every 12 h for a creatinine clearance of 100 mL/min. Keeping the interval, the dose is reduced in proportion to the creatinine clearance. Find the adjusted dose D. Round to the nearest whole number.
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