Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 7 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 6 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 35 mg/L. The half-life is 8 h, and the drug is eliminated by first-order kinetics. What is the level C 16 h later?
Practice exercise (made-up values, not clinical guidance). A 76 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 12 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 180 mg of gentamicin. The level back-extrapolated to time zero is 12 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 71 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.05 L/kg/h. Each dose is 300 mg of aminophylline. Find the average steady-state level Css,avg.
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 3.5 L/h. Each dose is 1000 mg of vancomycin. Find the average steady-state level Css,avg.
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