Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of phenobarbital, which has a half-life of 80 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). In a patient, lidocaine has an elimination half-life of 2 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 210 mg of tobramycin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 850 mL/min. What infusion rate R in mg/min keeps the steady-state level at 2 mg/L?
Practice exercise (made-up values, not clinical guidance). An 89 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.03 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). An 82 kg patient on regular tobramycin doses is at steady state. The target is a peak of 6 mg/L and a trough of 1 mg/L, and the volume of distribution is 0.3 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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