Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 25 mg/L. The half-life is 10 h, and the drug is eliminated by first-order kinetics. What is the level C 3 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 9 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 1.5 h later?
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 25 mg/L at 1 h and 13.5 mg/L at 9 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 68 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 10 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 25 mg/h with no loading dose. The patient's clearance is 2.5 L/h and the half-life is 8 h. What is the level C after 9 h?
Practice exercise (made-up values, not clinical guidance). A 71-year-old man weighs 70 kg and has a serum creatinine of 2.5 mg/dL (221 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual gentamicin regimen is 80 mg every 8 h for a creatinine clearance of 120 mL/min. Keeping the dose, the interval is lengthened in proportion to the fall in clearance. Find the new dosing interval τ. Round to one decimal place.
Full step-by-step solutions: practise this topic on examproblems.com.