Practice exercise (made-up values, not clinical guidance). A patient receives aminophylline as a constant IV infusion without a loading dose. The half-life is 6 h. What percentage f of the steady-state level has been reached after 21 h?
Practice exercise (made-up values, not clinical guidance). In a patient, digoxin has an elimination half-life of 36 h. Find the elimination rate constant k in h⁻¹.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 220 mg of tobramycin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 2 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 260 mg of tobramycin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 2.5 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 30 mg/h with no loading dose. The patient's clearance is 2.5 L/h and the half-life is 8 h. What is the level C after 11 h?
Practice exercise (made-up values, not clinical guidance). An 80 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.045 L/kg/h. Each dose is 200 mg of aminophylline. Find the average steady-state level Css,avg.
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