Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 8 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 1.5 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 68 kg needs a loading dose of tobramycin to reach a level of 6 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 270 mg of gentamicin. The level back-extrapolated to time zero is 12 mg/L and the half-life is 3 h. Find the volume of distribution Vd.
Practice exercise (made-up values, not clinical guidance). A 72 kg patient is to receive an aminophylline infusion (salt factor S = 0.8: 80% of aminophylline is theophylline). The theophylline clearance is 0.04 L/kg/h. What aminophylline infusion rate R in mg/h gives a steady-state theophylline level of 12 mg/L?
Practice exercise (made-up values, not clinical guidance). An 85 kg patient has a digoxin level of 0.2 mcg/L; the target is 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). An 89 kg patient takes oral theophylline (F = 1) every 8 h. The clearance is 0.045 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
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