Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of theophylline, which has a half-life of 6 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). The elimination rate constant of lidocaine in a patient is 0.347 h⁻¹. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 63 kg patient receives a theophylline infusion. The clearance is 0.035 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 10 mg/L at 1 h and 3.7 mg/L at 6 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 37.5 mg/h with no loading dose. The patient's clearance is 2.5 L/h and the half-life is 6 h. What is the level C after 5 h?
Practice exercise (made-up values, not clinical guidance). A 67 kg patient takes oral theophylline (F = 1) every 12 h. The clearance is 0.04 L/kg/h. Each dose is 300 mg of theophylline. Find the average steady-state level Css,avg.
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