Practice exercise (made-up values, not clinical guidance). A patient who weighs 103 kg needs a loading dose of vancomycin to reach a level of 20 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 10 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 5 h later?
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 25 mg/L at 2 h and 12.5 mg/L at 14 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 100 mg of tobramycin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A 100 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.04 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). A 64 kg patient has a digoxin level of 0.5 mcg/L; the target is 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have F = 0.7. What extra loading dose LD raises the level to the target?
Full step-by-step solutions: practise this topic on examproblems.com.