Practice exercise (made-up values, not clinical guidance). A patient who weighs 52 kg needs a loading dose of tobramycin to reach a level of 10 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient who weighs 58 kg needs a loading dose of gentamicin to reach a level of 6 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 7 mg/L at 1 h and 1.8 mg/L at 6 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 5 L/h. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 4 h. The target is a peak of 10 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 95% of the steady-state level?
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