1.Easy
In which clinical trial phase is a new drug usually first given to humans, often healthy volunteers?
- APhase II
- BPhase III
- CPhase I
- DPhase IV
2.Easy
Tamoxifen is used mainly to treat:
- AProstate enlargement and prostate cancer in older men
- BOsteoarthritis
- COestrogen receptor-positive breast cancer
- DType 2 diabetes
3.Easy
What does the "potency" of a drug describe?
- AThe largest effect the drug can produce
- BHow long the drug stays in the body
- CHow safe the drug is compared with other drugs in its class
- DThe amount of drug needed to produce a given effect
4.Medium
Benzathine benzylpenicillin (penicillin G benzathine) is ordered. Which route is correct?
- AIntravenous infusion over 30 minutes
- BSubcutaneous in the abdomen
- CDeep intramuscular only
- DIntravenous push
5.Medium
How does glyceryl trinitrate (GTN) relieve angina?
- AIt increases the force of contraction so the heart pumps blood more efficiently
- BIt dissolves the clot in the coronary artery
- CIt blocks beta-1 receptors and slows the heart
- DIt releases nitric oxide, mainly dilating veins and reducing cardiac workload
6.Medium
Which description fits tardive dyskinesia?
- AInvoluntary movements of the lips, tongue and face after long-term antipsychotic use
- BHigh fever with lead-pipe rigidity and confusion
- CA sudden painful spasm of the neck muscles and upward rolling of the eyes within days of the first dose
- DA low white cell count with sore throat and fever
7.Hard
A patient who has had several courses of bleomycin develops a dry cough and worsening breathlessness. What should the nurse suspect?
- AHeart failure from bleomycin
- BPulmonary fibrosis from bleomycin
- CA normal effect that will pass in a day
- DAsthma caused by anxiety
8.Hard
Beta-lactam antibiotics show time-dependent killing. What does this mean for administration?
- ADoses should be given only when the patient has a fever
- BDoses should be given on time at evenly spaced intervals
- CDoses can be given at any time as long as the daily total is right
- DA single very large daily dose works best
Answer key
- 1. C · Phase I
- 2. C · Oestrogen receptor-positive breast cancer
- 3. D · The amount of drug needed to produce a given effect
- 4. C · Deep intramuscular only
- 5. D · It releases nitric oxide, mainly dilating veins and reducing cardiac workload
- 6. A · Involuntary movements of the lips, tongue and face after long-term antipsychotic use
- 7. B · Pulmonary fibrosis from bleomycin
- 8. B · Doses should be given on time at evenly spaced intervals
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