1.Easy
Amphotericin B is used mainly for:
- ABacterial urinary tract infections
- BSerious systemic fungal infections
- CInfluenza in older people
- DMild athlete's foot
2.Easy
In Addison's disease, fludrocortisone is given to replace which hormone?
- AAldosterone
- BAdrenaline
- CThyroxine
- DCortisol
3.Easy
Why is adrenaline (epinephrine) sometimes added to a local anaesthetic injection?
- AIt speeds up the removal of the anaesthetic from the tissue into the blood
- BIt makes the anaesthetic act on the brain as well
- CIt constricts vessels, so the block lasts longer and less enters the blood
- DIt prevents allergic reactions to the anaesthetic
4.Medium
A malnourished patient with alcohol dependence needs IV glucose. Which vitamin should be given before or with it?
- AThiamine (vitamin B1)
- BVitamin D
- CVitamin C
- DVitamin K (phytomenadione)
5.Medium
A patient is starting lamotrigine. Which adverse effect should the patient report at once?
- AAny new skin rash
- BMild headache on the first day
- CA brief change in taste
- DSlight tiredness in the afternoon
6.Medium
How should a patient take oral alendronate?
- ACrushed into yoghurt with calcium supplements
- BWith plain water on an empty stomach, staying upright for 30 minutes
- CWith breakfast and coffee to protect the stomach
- DWith milk at bedtime, then lying down straight away to aid absorption
7.Hard
A patient on methadone is also prescribed diazepam for anxiety. What is the main safety concern?
- ASevere hypertension from the combination
- BMethadone causes diazepam to be excreted very quickly
- CAdditive sedation and respiratory depression
- DDiazepam blocks the effect of methadone completely
8.Hard
Why is vancomycin given by mouth, not intravenously, for Clostridioides difficile infection?
- AOral vancomycin is absorbed into the blood better than IV vancomycin
- BOral vancomycin is not absorbed, so it reaches high levels in the colon
- CIntravenous vancomycin causes C. difficile infection
- DThe oral form is cheaper but has the same effect as IV
Answer key
- 1. B · Serious systemic fungal infections
- 2. A · Aldosterone
- 3. C · It constricts vessels, so the block lasts longer and less enters the blood
- 4. A · Thiamine (vitamin B1)
- 5. A · Any new skin rash
- 6. B · With plain water on an empty stomach, staying upright for 30 minutes
- 7. C · Additive sedation and respiratory depression
- 8. B · Oral vancomycin is not absorbed, so it reaches high levels in the colon
Full step-by-step solutions: practise this topic on examproblems.com.