1.Easy
Methylphenidate, used in ADHD, belongs to which class?
- AOpioid analgesics
- BAntipsychotics (dopamine blockers)
- CCentral nervous system stimulants
- DBenzodiazepines
2.Easy
What is drug tolerance?
- AA stronger response each time the drug is taken
- BThe ability to take a drug without developing any side effects at all
- CA reduced response after repeated use, so a higher dose is needed
- DAn allergic reaction to a drug
3.Easy
Which drug is the antidote for paracetamol (acetaminophen) overdose?
- AAcetylcysteine
- BVitamin K
- CNaloxone
- DFlumazenil
4.Medium
When should a patient take a once-daily proton pump inhibitor such as omeprazole?
- AStraight after a large evening meal
- BWith a glass of milk at bedtime, when acid output is highest
- COnly when heartburn is severe
- DAbout 30–60 minutes before the first meal of the day
5.Medium
Which patient should usually not use the combined oral contraceptive pill?
- AA 38-year-old woman who smokes 20 cigarettes a day
- BA 22-year-old non-smoker with acne
- CA 25-year-old woman with heavy periods
- DA 30-year-old non-smoker with no medical problems
6.Medium
A man takes finasteride. What should be explained about handling the tablets?
- APregnant women should not handle crushed or broken tablets
- BThe tablets must be crushed before swallowing
- CAnyone can handle the tablets, as they contain no active drug
- DThe tablets must be stored in the fridge
7.Hard
A patient who takes clonidine stopped it suddenly two days ago. He is now agitated, has a headache and his blood pressure is very high. What is the most likely explanation?
- AAn allergic reaction to clonidine
- BRebound hypertension from abrupt clonidine withdrawal
- CClonidine toxicity due to slow excretion by the kidneys
- DNormal variation unrelated to the medication
8.Hard
A patient receiving a phenylephrine infusion has a rise in blood pressure and a fall in heart rate. What is the best explanation?
- AThe fall in heart rate shows phenylephrine toxicity of the AV node
- BPhenylephrine stimulates muscarinic receptors
- CPhenylephrine directly blocks beta-1 receptors in the heart's conduction system
- DAlpha-1 vasoconstriction raises blood pressure and causes reflex bradycardia
Answer key
- 1. C · Central nervous system stimulants
- 2. C · A reduced response after repeated use, so a higher dose is needed
- 3. A · Acetylcysteine
- 4. D · About 30–60 minutes before the first meal of the day
- 5. A · A 38-year-old woman who smokes 20 cigarettes a day
- 6. A · Pregnant women should not handle crushed or broken tablets
- 7. B · Rebound hypertension from abrupt clonidine withdrawal
- 8. D · Alpha-1 vasoconstriction raises blood pressure and causes reflex bradycardia
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