1.Easy
What is an adverse drug reaction?
- AA harmful, unintended response to a drug at normal doses
- BAny effect of a drug that the patient notices
- CThe intended therapeutic effect of a drug
- DA reaction that occurs only after an overdose
2.Easy
Filgrastim, a granulocyte colony-stimulating factor (G-CSF), is given to:
- AIncrease the production of platelets
- BIncrease the production of neutrophils
- CLower the white cell count in leukaemia
- DStop bleeding from wounds
3.Easy
Nitrofurantoin is used mainly to treat:
- ABacterial meningitis in adults and children
- BBone infections
- CUncomplicated cystitis (lower urinary infection)
- DPneumonia
4.Medium
A woman taking the combined pill should seek care urgently for which symptom?
- AMild breast tenderness in the first month
- BA painful, swollen calf or sudden chest pain
- CSlight nausea in the first few weeks
- DLight spotting between periods early on
5.Medium
A person who has never been vaccinated against tetanus has a deep, dirty wound. What is usually given?
- AOral antibiotics only
- BTetanus vaccine and tetanus immunoglobulin
- CTetanus vaccine only, after the wound heals
- DNo treatment unless symptoms appear
6.Medium
A partial agonist is given together with a high dose of a full agonist. What happens to the response?
- AIt falls, because the partial agonist competes for the receptors
- BIt stays exactly the same as with the high dose of full agonist alone
- CIt rises above the maximum of the full agonist
- DIt doubles, because both drugs activate the receptor
7.Hard
Which antiepileptic drug carries the highest well-known risk of neural tube defects and developmental problems when taken in pregnancy?
- ASodium valproate
- BLamotrigine
- CGabapentin
- DLevetiracetam
8.Hard
Before starting rituximab, patients are tested for hepatitis B. Why?
- ARituximab is a vaccine against hepatitis B
- BRituximab is made from the hepatitis B virus
- CHepatitis B infection makes rituximab completely ineffective
- DRituximab can reactivate hepatitis B and cause liver failure
Answer key
- 1. A · A harmful, unintended response to a drug at normal doses
- 2. B · Increase the production of neutrophils
- 3. C · Uncomplicated cystitis (lower urinary infection)
- 4. B · A painful, swollen calf or sudden chest pain
- 5. B · Tetanus vaccine and tetanus immunoglobulin
- 6. A · It falls, because the partial agonist competes for the receptors
- 7. A · Sodium valproate
- 8. D · Rituximab can reactivate hepatitis B and cause liver failure
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