感染控制与患者安全
方法
- 对每位患者都从标准预防开始:手卫生、针对预期暴露的个人防护装备、安全使用锐器。
- 按传播途径追加预防措施:接触传播(隔离衣、手套)、飞沫传播(外科口罩)、空气传播(N95、负压病房)。
- 保持无菌物品的无菌状态:如有疑问就视为不无菌;更换,绝不擦拭。
- 预防环境中的伤害:防跌倒措施,约束仅作为最后手段,火灾时用 RACE 和 PASS。
- 核对给药的正确原则、两个身份识别信息,以及对高警示药物的额外保障;报告差错和险兆事件。
公式表、每个专题的关键方法步骤和 40 道练习题,完整解答附在最后。
Which approach suits teaching an older adult with poor eyesight and mild memory problems?
A patient on regular paracetamol (acetaminophen) also takes an over-the-counter cold and flu remedy. Why is this a concern?
输液泵的药物库提示设定剂量超过安全上限。护士应怎么做?
A patient with pulmonary tuberculosis has been on treatment. Which findings usually allow airborne isolation to end?
A patient receiving an aminoglycoside antibiotic, such as gentamicin, reports ringing in the ears. What should the nurse do?
An adult choking on food is coughing forcefully and can speak a little. What should the nurse do?
Why should a urinary catheter drainage bag be kept below the level of the bladder?
一名头部外伤患者出现血压升高、心率减慢和呼吸不规则。这提示:
A patient taking empagliflozin (an SGLT2 inhibitor) has glucose in the urine but a normal blood glucose. What is the best interpretation?
During surgery under general anesthesia, a patient develops a rising end-tidal CO2, muscle rigidity and tachycardia, then a high potassium and a rising temperature. Which condition is most likely?
An adult patient is due to receive digoxin. The apical pulse, counted for a full minute, is 52 beats per minute. What should the nurse do?
A patient on simvastatin is prescribed gemfibrozil. What is the main concern?
A patient with a mechanical heart valve asks to switch from warfarin to apixaban. What is the correct response?
A patient has sudden severe chest pain spreading to the back between the shoulder blades. Which finding most supports aortic dissection rather than myocardial infarction?
甲状腺切除术后,为什么常在床边备有拆线或拆夹器?
The nurse has four patients. Which one needs to be seen first?
Why does a patient need lifelong vitamin B12 injections after total gastrectomy?
Which new prescription for a patient with cirrhosis should the nurse question?
1 分钟时,新生儿心率为 90 次/分。在 APGAR 评分中,心率得几分?
A newborn whose mother had a fever and prolonged rupture of membranes is well at birth. Why does the nurse monitor this baby closely?
A child with type 1 diabetes is unconscious from hypoglycaemia at school. What should be done?
The safe dose range of a drug is 25–50 mg/kg per day, divided every 8 hours. A 12 kg child is prescribed 250 mg every 8 hours. What should the nurse do?
Which pattern suggests premenstrual dysphoric disorder?
A community nurse visits an older woman with hoarding disorder whose home is so cluttered that the exits are blocked. What is the most appropriate approach?
练习题(虚构数值,不作为临床指导)。 一个剂量记录在 6:50 AM。哪个条目是 24 小时制中的同一时间?点击它。
练习题(虚构数值,不作为临床指导)。 一次输注从 22:40 开始,到次日早晨 02:05 结束(24 小时制)。它运行了多少小时t?答案以小数表示小时数,取到两位小数。
一名体重 16 kg 的儿童按 10 mg/kg 处方用药。原液浓度为 40 mg/mL。请抽取剂量:应给多少体积 V?
一名体重 20 kg 的儿童,医嘱为口服混悬液每次 15 mg/kg,该混悬液每 5 mL 含 125 mg。你应给多少体积 V?
滴注以 50 gtt/min 的速度通过滴系数为 20 gtt/mL 的输液器。患者在 3 小时内接受多少毫升 V?
一袋中含有 4 g 药物,溶于 1000 mL。医嘱为每分钟 1 mg。泵速 R 应设为多少 mL/h?
练习题(虚构数值,不作为临床指导)。 一项练习规程要求为体重 100 kg 的患者推注肝素 60 units/kg。药瓶规格为 1 000 units/mL。应抽取多少体积 V? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 一袋中含dobutamine 250 mg,容量 250 mL。医嘱为 5 mcg/kg/min,患者体重 84 kg。输液泵速率 R 应设为多少 mL/h? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 记录显示了一名患者在一个 12 小时班次中的出入量。患者体重 68 kg。求平均尿量 U,以 mL/kg/h 计。 保留两位小数。
练习题(虚构数值,不作为临床指导)。 一袋 1000 mL 的液体用输液泵以 50 mL/h 输注。到 13:00 时已输入 700 mL。还要多少小时 t 袋子才会输完? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 用 Morse 跌倒评分评估一位练习患者:过去 3 个月内的跌倒史: 否; 次要诊断: 是; 行走辅助: 无、卧床休息或由护士协助; 静脉输液或封管: 是; 步态: 虚弱; 精神状态: 高估或忘记自身局限。求 Morse 总分MFS。
练习题(虚构数值,不作为临床指导)。 对这些观察结果使用 NEWS2 图表(SpO₂ 量表 1):呼吸频率 23 次/分,SpO₂ 98%吸室内空气,血压 150/90 mmHg,脉搏 82 次/分,清醒,体温 36.6 °C。患者属于哪个临床风险组?点击它。
某练习动脉血气显示 pH 7.23,PaCO₂ 71 mmHg (9.5 kPa),HCO₃⁻ 29 mmol/L。原发性紊乱是呼吸性酸中毒。代偿到什么程度?点选你的答案。
某练习血气显示代谢性碱中毒,HCO₃⁻ 34 mmol/L。用预期 PaCO₂ = 0.7·HCO₃⁻ + 21 求预期PaCO₂。
在这条规则的 II 导联心电图上测量 QT 间期和 R–R 间期,然后用 Bazett 公式 QTc = QT/√RR(均以秒计)计算经心率校正的QTc。答案以秒表示,保留三位小数。
这位患者装有起搏器。请解读这条 II 导联心电图条带。点击你的答案。
答案: D · Short sessions, large-print materials and repeating key points
Older learners benefit from short, focused sessions, clear large print, good lighting, repetition and teach-back. Involving family can help but should not replace teaching the patient.
答案: B · Many cold remedies also contain paracetamol, risking liver damage
Paracetamol is in many combination products. Taking several at once can push the total over the safe daily maximum and cause liver damage, so patients are taught to check labels.
答案: A · 首先重新核对医嘱、计算和泵的设置
智能输液泵的限值用于发现编程和计算错误。护士应先核对医嘱、浓度、剂量和速率,再决定是否确实适合忽略警报。
答案: D · Three negative sputum smears, clinical improvement and continued therapy
Airborne precautions usually continue until the patient is on effective therapy, is improving clinically and has three negative sputum smears for acid-fast bacilli, according to policy.
答案: D · Hold the next dose and report it promptly
Aminoglycosides can cause ototoxicity, which may be permanent. Tinnitus or hearing loss is reported promptly, and drug levels and kidney function are checked.
答案: C · Encourage the patient to keep coughing and stay with them
A partial obstruction with a forceful cough is best cleared by the patient’s own coughing. The nurse stays and is ready to act if the cough becomes weak or the patient cannot speak or breathe.
答案: B · To prevent urine flowing back into the bladder
Keeping the bag below the bladder allows drainage and prevents backflow, which reduces infection risk. The bag should also not touch the floor.
答案: A · 颅内压增高(库欣三联征)
库欣三联征(高血压伴脉压增大、心动过缓和呼吸不规则)是颅内压增高的晚期征象,需要紧急处理。
答案: B · An expected effect of the drug
SGLT2 inhibitors block glucose reabsorption in the proximal tubule, so glycosuria is expected even with normal blood glucose. Urine glucose cannot be used to monitor control in these patients. The drugs also raise the risk of genital infections and DKA.核对依据: Ketones blood test · MedlinePlus (NIH) (2025)
答案: A · Malignant hyperthermia
Malignant hyperthermia is a genetic hypermetabolic reaction to volatile anesthetics or succinylcholine. Muscle cells release calcium, producing CO2, heat, rigidity, hyperkalemia and very high CK. It is treated with dantrolene and stopping the trigger.
答案: D · Withhold the dose and notify the prescriber
Digoxin is usually withheld in adults if the apical pulse is below 60 per minute, and the prescriber is informed. Bradycardia may be an early sign of toxicity.
答案: A · A much higher risk of myopathy and rhabdomyolysis
Gemfibrozil reduces statin clearance and adds its own muscle toxicity. The combination greatly increases the risk of rhabdomyolysis and is generally avoided.
答案: B · Direct oral anticoagulants are not used for mechanical valves
Mechanical valves need lifelong anticoagulation with a vitamin K antagonist such as warfarin. Direct oral anticoagulants caused more clots and bleeding in mechanical valve patients and are contraindicated. Biological valves usually need only short-term anticoagulation.
答案: A · A large difference in blood pressure between the arms
A difference of more than about 20 mmHg in systolic pressure between the arms, a pulse deficit or a new aortic regurgitation murmur suggests dissection. Sweating, tachycardia and rest pain also occur in MI. Thrombolysis and anticoagulants could be disastrous in dissection, so the distinction matters.
答案: B · 颈部血肿可压迫气道,可能需要松解
甲状腺手术后颈部血肿可迅速压迫气道。许多病房在床边备有拆夹器或拆线器及气道设备,以便在紧急情况下打开伤口。护士应观察有无肿胀、喘鸣和呼吸困难。
答案: D · A patient on insulin for DKA whose potassium is now 2.9 mmol/L
Insulin drives potassium into cells, and a potassium of 2.9 mmol/L during DKA treatment can cause life-threatening arrhythmias. The insulin rate and potassium replacement need urgent review under the protocol. The other patients are stable.
答案: D · Intrinsic factor from the stomach is no longer made
Parietal cells of the stomach make intrinsic factor, which is needed for B12 absorption in the terminal ileum. Without it, pernicious-type anaemia and neuropathy develop unless B12 is given by injection.
答案: C · Regular ibuprofen for back pain
NSAIDs can cause kidney injury, fluid retention and GI bleeding in cirrhosis and should be avoided. Paracetamol at a reduced, carefully reviewed dose is usually preferred for pain.
答案: B · 1
心率无则计 0 分,低于 100 次/分计 1 分,100 次/分或以上计 2 分。APGAR 的五项指标各计 0–2 分,因此每项最高为 2 分。
答案: C · The baby has a higher risk of early sepsis
Maternal fever, prolonged rupture of membranes and intra-amniotic infection are risk factors for early-onset sepsis. Many protocols require observation of vital signs and feeding, and sometimes blood tests or antibiotics.
答案: D · Give glucagon and call emergency services
An unconscious child cannot swallow safely, so glucagon is given by injection or nasal spray, the child is placed in the recovery position and emergency help is called. Once awake and able to swallow, carbohydrate is given.
答案: B · Contact the prescriber, because 750 mg a day is above the maximum of 600 mg
Safe range = 12 × 25 to 12 × 50 = 300–600 mg/day. Prescribed = 250 × 3 = 750 mg/day, which is above the maximum. The nurse withholds the dose and clarifies with the prescriber, never adjusting it alone.
答案: D · Marked mood symptoms in the week before menstruation that improve within a few days after it starts
In PMDD, symptoms such as irritability, low mood, anxiety and mood swings occur in the final week before menses, improve after onset and are minimal in the week after. Symptoms should be confirmed with daily ratings over at least two cycles.
答案: D · Work with her to clear the exits first, then agree a gradual plan together
Forced clear-outs cause great distress and the clutter usually returns. Collaborative, gradual work focusing first on safety, such as fire exits and fall risks, with involvement of relevant services, is more effective.
答案: 06:50
24 小时制:下午 1 点起,小时数加 12(下午 3:45 = 15:45)。午夜到凌晨 12:59 为 00:00–00:59,中午 12:00–12:59 仍为 12:00–12:59。反过来换算时,13–23 点减 12 并标为下午;00 点变为凌晨 12 点。跨午夜计算时间要分两段:先算到 24:00(00:00),再从 00:00 算起。
答案: t = 3.42 h
24 小时制:下午 1 点起,小时数加 12(下午 3:45 = 15:45)。午夜到凌晨 12:59 为 00:00–00:59,中午 12:00–12:59 仍为 12:00–12:59。反过来换算时,13–23 点减 12 并标为下午;00 点变为凌晨 12 点。跨午夜计算时间要分两段:先算到 24:00(00:00),再从 00:00 算起。
答案: V = 4 mL
抽取剂量:体积 = (处方剂量/药物浓度) × 药物体积。先换算成相同的单位,再检查该体积是否适合注射器,并落在它的某一个刻度上。
在这支 10 mL 的注射器上,每条小刻度线代表 0.2 mL。
答案: V = 12 mL
剂量计算:给药量等于医嘱剂量除以现有药物的规格,再乘以该规格对应的量:给药量 = (医嘱剂量/储备规格) × 储备体积。始终统一单位(先把 g 换成 mg,mg 换成 mcg),并检查答案是否合理。
答案: V = 450 mL
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
答案: R = 15 mL/h
Dose-based infusions: concentration = amount of drug in the bag/bag volume. Pump rate (mL/h) = dose per hour/concentration, and dose per hour = mL/h × concentration. Convert per-minute doses to per-hour (× 60) and keep the mass units the same (1 g = 1000 mg, 1 mg = 1000 mcg).
答案: V = 6 mL
肝素和胰岛素输注:浓度 = 袋中单位数/袋容量 (units/mL)。泵速 (mL/h) = 每小时单位数/浓度,每小时单位数 = mL/h × 浓度。按体重给药时,先求 units/h = units/kg/h × 体重。推注体积 = 所需单位数/药瓶规格。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: R = 25.2 mL/h
滴定输注:先求以 mcg/mL 计的浓度(mg × 1000/mL)。按体重给药时,mcg/min = mcg/kg/min × 体重。然后 mL/h = mcg/min × 60/浓度。反推时,mcg/kg/min = mL/h × 浓度/(60 × 体重)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: U = 1.19 mL/kg/h
出入量:入量计入所有进入体内的液体(口服液体、静脉输液、静脉用药及冲管液、管饲);冰屑按其体积的一半计。出量计入尿液、引流液、呕吐物和其他丢失。平衡 = 总入量 − 总出量;平衡为负表示净丢失。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: t = 6 h
输液时间:时间 (h) = 待输体积 (mL)/速率 (mL/h);使用袋中剩余的体积,而不是袋的容量。已输入体积 = 速率 × 时间。把小数小时换算为小时和分钟时,用小数部分 × 60(0.5 h = 30 min,而不是 50 min)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
约为 6 h 00 min,所以袋子大约在 19:00 输完。
答案: MFS = 60
Morse 跌倒评分:六个条目。跌倒史:否 0 分,是 25 分。次要诊断:否 0 分,是 15 分。行走辅助:无、卧床休息或护士协助 0 分;拐杖、手杖或助行器 15 分;扶着家具 30 分。静脉输液或封管:否 0 分,是 20 分。步态:正常、卧床休息或轮椅 0 分;虚弱 10 分;受损 20 分。精神状态:了解自身局限 0 分;高估或忘记自身局限 15 分。总分为 0 至 125。各医院的风险分界值不同;常用的一套是 0–24 低风险,25–44 中度风险,45 及以上为高风险。
答案: 低
NEWS2(国家早期预警评分 2,英国皇家内科医师学会 2017):按图表为七个参数分别评分(呼吸频率、量表 1 的 SpO₂、吸空气还是吸氧、收缩压、脉搏、按 ACVPU 量表评定的意识状态和体温),然后把分数相加。临床风险:0–4 为低;任何单项参数得 3 分为中低;5–6 为中;7 或以上为高。总分 5 或以上需要紧急响应。
答案: 部分代偿
解读血气(ROME):先看 pH:低于 7.35 为酸血症,高于 7.45 为碱血症。然后找出能解释它的指标。PaCO₂(正常 35–45 mmHg,4.7–6.0 kPa)是呼吸方面的指标,在呼吸性紊乱中与 pH 反向(Opposite)变化;HCO₃⁻(正常 22–26 mmol/L)是代谢方面的指标,与 pH 同向变化(Respiratory Opposite, Metabolic Equal,即呼吸性相反,代谢性相同)。另一个指标显示代偿情况:正常表示未代偿;沿着使 pH 回升的方向异常、而 pH 仍然异常,表示部分代偿;pH 正常而两个指标都异常,表示完全代偿。各实验室的范围略有差异;这些是练习用数值。
答案: PaCO₂ = 44.8 mmHg
预期代偿:代谢性酸中毒时,温特公式预测 PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg;实测值高于该范围提示合并呼吸性酸中毒,低于该范围提示合并呼吸性碱中毒。阴离子间隙 AG = Na⁺ − (Cl⁻ + HCO₃⁻),正常约为 8–12 mmol/L,用于区分高阴离子间隙与正常阴离子间隙代谢性酸中毒;低白蛋白会掩盖升高的间隙(白蛋白低于 4.0 的部分,每 g/dL 加 2.5)。Δ 比值 (AG − 12)/(24 − HCO₃⁻) 约在 0.8 到 2 之间符合单纯高间隙酸中毒(有些教材用 1 代替 0.8),低于此范围提示合并正常间隙酸中毒,高于 2 提示合并代谢性碱中毒。
升高是有限度的:仅靠代偿,PaCO₂ 很少超过约 55 mmHg。
答案: QTc = 0.454 s
QT 与 QTc:QT 间期从 QRS 波群起点到 T 波终点。它随心率加快而缩短,因此要用以秒为单位的 R–R 间期按心率校正:Bazett QTc = QT/√RR,Fridericia QTc = QT/∛RR。多数教科书使用 Bazett 公式;它在心率快时校正过度,此时宜用 Fridericia。各参考标准的界限不同:QTc 男性高于约 0.45 s、女性高于约 0.46 s 通常称为延长,高于 0.50 s 称为明显延长。
介于男性(约 0.45 s)和女性(约 0.46 s)的通常上限之间:临界,取决于所用的参考标准。(454 ms)
答案: 起搏心律,夺获失败
起搏心律:起搏器脉冲表现为一条细而垂直的起搏钉样信号。心室钉样信号之后的 QRS 是增宽的(0.12 s 或以上),因为冲动是从导线经心肌传播,而不是经传导系统;右心室起搏时,在 II 导联上通常以负向为主。P 波之前的钉样信号表示心房起搏;双腔(房室)起搏器则表现为心房钉样信号加 P 波,再经过程控的房室延迟,出现心室钉样信号和增宽的 QRS。夺获是指每个钉样信号之后都跟着一次除极。夺获失败是指钉样信号之后没有 P 波或 QRS;感知不良(钉样信号无视患者自己的心搏)和起搏不良(该出现钉样信号时没有)是另外两种典型的故障。
夺获失败:起搏器发放了脉冲,但心脏没有反应。教科书把它视为需要紧急报告的情况,因为患者可能依赖起搏器。
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