感染控制与患者安全
方法
- 对每位患者都从标准预防开始:手卫生、针对预期暴露的个人防护装备、安全使用锐器。
- 按传播途径追加预防措施:接触传播(隔离衣、手套)、飞沫传播(外科口罩)、空气传播(N95、负压病房)。
- 保持无菌物品的无菌状态:如有疑问就视为不无菌;更换,绝不擦拭。
- 预防环境中的伤害:防跌倒措施,约束仅作为最后手段,火灾时用 RACE 和 PASS。
- 核对给药的正确原则、两个身份识别信息,以及对高警示药物的额外保障;报告差错和险兆事件。
公式表、每个专题的关键方法步骤和 40 道练习题,完整解答附在最后。
Why must a respirator such as an FFP3 or N95 mask be fit-tested?
A colleague asks the nurse to countersign the controlled drug register for a dose the nurse did not see being prepared or given. What should the nurse do?
When should the transparent dressing over a peripheral IV site be changed?
一名患者正在持续输注高警示药物。交接班时,哪种做法最安全?
A patient’s urinary catheter has drained no urine for two hours, and the lower abdomen is swollen. What should the nurse do first?
一名心力衰竭患者气短,双肺有湿啰音。哪种行动顺序是正确的?
A patient on insulin reports nightmares, night sweats and morning headaches. What should be suspected?
Which route and site are recommended for the first dose of adrenaline (epinephrine) in anaphylaxis on a ward?
A patient with chronic kidney disease receives an erythropoiesis-stimulating agent such as epoetin alfa. Which assessments are most important?
A patient has a sodium of 150 mEq/L, a glucose of 180 mg/dL and a BUN of 28 mg/dL. Using the formula 2 × Na + glucose/18 + BUN/2.8, what is the calculated serum osmolality?
While giving medicines, a patient says, "That pill looks different from the one I usually take." What should the nurse do?
A patient has received a sodium nitroprusside infusion for several days. He becomes confused and develops a metabolic acidosis. What should be suspected?
Why is pyridoxine (vitamin B6) often given with isoniazid?
在严重哮喘发作期间,一名患者的 PaCO₂ 从偏低升至正常,同时看起来精疲力竭。这意味着什么?
The day after a thyroidectomy, a patient reports tingling around the mouth and in the fingers. Why might this happen?
A patient with a cervical spinal cord injury is helped to sit up for the first time. They become dizzy and pale, and the BP falls from 110/70 to 78/46 mmHg. What should the nurse do?
Which group of findings suggests obstruction of the bile duct?
On day 5 after a major burn, a patient is confused, with a temperature of 39.2 °C, tachycardia, and an offensive, discoloured wound. What should the nurse suspect?
分娩机转最初几个动作的正确顺序是什么?
A biophysical profile scores 4 out of 10 at 38 weeks. How should the nurse interpret this?
下列哪一组表现是儿童肾病综合征的典型表现?
一名 6 岁的血友病患儿摔倒后膝盖肿胀疼痛。优先事项是什么?
Which side effects are most common with quetiapine?
A patient with anorexia nervosa is admitted with a BMI of 14, dizziness and low potassium. Which goal is the priority in the first days?
练习题(虚构数值,不作为临床指导)。 一个剂量记录在 04:25(24 小时制)。哪个条目是 12 小时制中的同一时间?点击它。
练习题(虚构数值,不作为临床指导)。 一个班次中,患者摄入了2 fl oz / 果汁, 4 tbsp / 液体营养补充剂, 1½ tsp / 止咳糖浆, 2 杯 / 茶。按给出的等量关系,求以 mL 表示的口服总摄入量V。
某患者体重 12 kg,医嘱为单次给药 7.5 mg/kg。求剂量 D(mg)。
一名患者身高 183 cm,体重 77 kg。医嘱为 250 mg/m²。用 Mosteller 公式 BSA = √(身高 (cm) × 体重 (kg)/3600) 求剂量 D,以 mg 表示。
用滴系数为 20 滴/mL 的输液器在 5 小时内输入 1000 mL。求滴速 R(滴/分)。 取整到最接近的整数。
一组输液以 28 滴/分的速度经 20 滴/mL 的输液器滴注。袋中还剩 200 mL。还需多少小时 t 才会滴完? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 一项练习规程要求为体重 94 kg 的患者推注肝素 70 units/kg。药瓶规格为 5 000 units/mL。应抽取多少体积 V? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 一袋中含dopamine 800 mg,容量 500 mL。医嘱为 5 mcg/kg/min,患者体重 88 kg。输液泵速率 R 应设为多少 mL/h? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 记录显示了一名患者在一个 8 小时班次中的出入量。患者体重 46 kg。求平均尿量 U,以 mL/kg/h 计。 保留两位小数。
练习题(虚构数值,不作为临床指导)。 一袋 1000 mL 的液体于 07:00 开始用输液泵以 80 mL/h 输注。到 12:00 时袋中还剩多少 mL V?
练习题(虚构数值,不作为临床指导)。 用 Morse 跌倒评分评估一位练习患者:过去 3 个月内的跌倒史: 是; 次要诊断: 否; 行走辅助: 拐杖、手杖或助行器; 静脉输液或封管: 是; 步态: 正常、卧床休息或轮椅; 精神状态: 了解自身局限。求 Morse 总分MFS。
练习题(虚构数值,不作为临床指导)。 对这些观察结果使用 NEWS2 图表(SpO₂ 量表 1):呼吸频率 18 次/分,SpO₂ 96%吸室内空气,血压 124/74 mmHg,脉搏 82 次/分,清醒,体温 37.4 °C。患者属于哪个临床风险组?点击它。
练习数值:Na⁺ 135 mmol/L,葡萄糖 28.3 mmol/L,尿素 12.6 mmol/L。计算血清渗透压 Osm = 2·Na⁺ + 葡萄糖 + 尿素,取最接近的整数。
某练习血气显示代谢性酸中毒:pH 7.28,PaCO₂ 22 mmHg (2.9 kPa),HCO₃⁻ 10 mmol/L。把实测的PaCO₂与温特公式比较。点选你的解读。
这条 II 导联心电图显示传导比例固定的心房扑动。求出心室率(单位:次/分)。
这条 II 导联心电图显示房室传导阻滞,心室节律不规则。使用 6 秒法求出心室率(单位:次/分)。
答案: B · It only protects if it seals closely to the wearer's face
A respirator filters tiny airborne particles only if air passes through the filter, not around a gap. Fit-testing and a fit-check every time it is worn make sure it seals.
答案: D · Refuse, as they can only sign for what they have witnessed
Countersigning means confirming that you witnessed the check and administration. Signing for something you did not see is dishonest and removes an important safety check.
答案: B · When it is damp, loose or visibly soiled
A dressing that is wet, loose or dirty no longer protects the insertion site and is changed using aseptic technique. Otherwise, it is changed according to policy.
答案: B · 两名护士对照处方共同核对输注泵和药袋
交接班时在床边核对,沿管路从药袋追溯到患者,并对照处方核对药物、浓度、剂量和速率,可及早发现编程错误。
答案: A · Check the tubing for kinks or obstruction
Sudden lack of drainage with a full bladder usually means a kinked or blocked catheter. The nurse checks the tubing and position first, then follows the policy for irrigation or replacement.
答案: D · 坐起,按医嘱给氧,然后联系医疗人员
坐直可减少回心血量并缓解呼吸,氧气治疗缺氧。然后联系医疗人员并准备利尿剂。平躺或静脉补液会加重肺淤血。
答案: C · Night-time hypoglycaemia
Nocturnal hypoglycaemia can cause sweating, restless sleep, nightmares and morning headache. Checking glucose overnight and reviewing insulin doses can confirm and correct it.
答案: D · Intramuscular injection into the anterolateral thigh
IM adrenaline into the outer thigh is absorbed quickly and is the first-line route. IV adrenaline is reserved for experienced specialists with full monitoring because of the risk of arrhythmias.
答案: D · Hemoglobin and blood pressure
Epoetin stimulates red cell production. Hemoglobin is monitored, because raising it too high increases the risk of hypertension, stroke and thrombosis. Blood pressure is monitored, and iron stores are checked, since iron is needed for a good response.核对依据: Erythropoietin Stimulating Agents · StatPearls (NCBI Bookshelf) (2024)
答案: A · About 320 mOsm/kg, which is high
Osmolality = 300 + 10 + 10 = 320 mOsm/kg, above the typical range of about 275–295 mOsm/kg. The high sodium is the main cause, which points to water loss or too little water intake.核对依据: Osmolality blood test · MedlinePlus (NIH) (2025)
答案: B · Stop and recheck the order and the medicine before giving it
A patient's concern can reveal a wrong drug or wrong patient error. The nurse rechecks the order and product, and may call the pharmacy; a different brand or strength may explain the change.
答案: C · Cyanide toxicity from nitroprusside breakdown
Nitroprusside releases cyanide, which is normally converted to thiocyanate. With high doses, long infusions or poor organ function, cyanide and thiocyanate can accumulate; the infusion is also protected from light.
答案: D · To prevent peripheral neuropathy
Isoniazid increases pyridoxine loss, which can cause peripheral neuropathy, especially in people with diabetes, alcohol dependence, malnutrition or HIV. Pyridoxine prevents this. Isoniazid can also cause hepatitis. Ethambutol affects vision; pyrazinamide can cause gout.
答案: A · 患者正在疲劳,随后可能发生呼吸衰竭
发作早期,过度通气会使 PaCO₂ 降低。呼吸困难且正在疲劳的患者 PaCO₂ 正常或升高,意味着通气功能衰竭,是危及生命的特征。需要紧急的高级医师和重症监护评估。
答案: A · The parathyroid glands may have been damaged, lowering calcium
The parathyroid glands lie behind the thyroid and can be damaged or removed during surgery. Low PTH leads to hypocalcaemia, causing tingling, cramps and, if severe, tetany or arrhythmias. Calcium is checked after surgery.
答案: B · Lower the patient back towards lying, then raise them gradually later
Loss of sympathetic tone causes orthostatic hypotension after high spinal injuries. The patient is reclined, and later raised gradually, often with compression stockings, an abdominal binder and sometimes medicines.
答案: A · Jaundice, dark urine, pale stools and itching
When bile cannot reach the gut, conjugated bilirubin enters the blood and urine (dark urine), stools lose their colour, and bile salts in the skin cause itching. Causes include gallstones and pancreatic cancer.
答案: B · Burn wound infection with sepsis
Burn patients are at high risk of infection. Wound changes with systemic deterioration suggest sepsis, needing urgent escalation, cultures, IV antibiotics and wound review. The hypermetabolic state causes mild fever, but not these wound changes.
答案: B · 衔接、下降、俯屈、内旋转、仰伸
分娩机转依次为衔接、下降、俯屈、内旋转、仰伸、外旋转(复位)和娩出。
答案: A · It is abnormal and needs prompt review
A score of 8 to 10 is normal, 6 is equivocal, and 4 or less is abnormal and suggests fetal hypoxia. At term, a low score usually leads to prompt review and consideration of birth.
答案: C · 大量蛋白尿、血清白蛋白降低和全身性水肿
肾病综合征时,蛋白丢失使白蛋白降低并引起水肿,常最先出现在眼周。咽痛后出现可乐色尿和高血压提示链球菌感染后肾小球肾炎。
答案: A · 按处方补充凝血因子,并对关节休息、冰敷、加压和抬高
早期补充凝血因子可止住出血。休息、冷敷、轻度加压和抬高可减轻肿胀。阿司匹林和热敷会增加出血。反复的关节出血会损害关节。
答案: C · Sedation, dizziness when standing and weight gain
Quetiapine commonly causes drowsiness, orthostatic hypotension and metabolic effects. It has a lower risk of extrapyramidal effects and raised prolactin than many other antipsychotics.
答案: B · Medical stabilisation, with careful refeeding and correction of electrolytes
Severe malnutrition and electrolyte imbalance can be life-threatening. Medical stabilisation and safe refeeding come first; psychological therapy becomes more effective once she is physically safer.
答案: 4:25 AM
24 小时制:下午 1 点起,小时数加 12(下午 3:45 = 15:45)。午夜到凌晨 12:59 为 00:00–00:59,中午 12:00–12:59 仍为 12:00–12:59。反过来换算时,13–23 点减 12 并标为下午;00 点变为凌晨 12 点。跨午夜计算时间要分两段:先算到 24:00(00:00),再从 00:00 算起。
答案: V = 607.5 mL
家用计量和体重:护理考试使用取整的等量关系:1 茶匙(tsp)= 5 mL,1 汤匙(tbsp)= 15 mL = 3 tsp,1 液量盎司(fl oz)= 30 mL = 2 tbsp,1 杯 = 8 fl oz = 240 mL。体重方面,1 kg = 2.2 lb,1 lb = 16 oz;长度方面,1 英寸 = 2.54 cm。设置换算时,要让你不需要的单位相互约去。
答案: D = 90 mg
剂量计算:给药量等于医嘱剂量除以现有药物的规格,再乘以该规格对应的量:给药量 = (医嘱剂量/储备规格) × 储备体积。始终统一单位(先把 g 换成 mg,mg 换成 mcg),并检查答案是否合理。
答案: D = 494.6 mg
Body-surface-area dosing: many cytotoxic and some paediatric doses are prescribed per square metre of body surface area: dose (mg) = dose per m² × BSA (m²). The Mosteller formula estimates BSA = √(height (cm) × weight (kg)/3600).
答案: R = 67 gtt/min
输注速率:输液泵按 mL/h = 体积/时间(小时)设定。重力滴注按每分钟滴数计:gtt/min = 体积 (mL) × 滴系数 (gtt/mL)/时间 (min)。 滴系数印在输液器包装上:普通输液器为 10、15 或 20 gtt/mL(输血器在美国常为 10 gtt/mL,在英国为 15),微量输液器为 60 gtt/mL。务必使用题目或包装给出的滴系数。
床旁取最接近的整滴:67 滴/分。
答案: t = 2.4 h
输注速率:输液泵按 mL/h = 体积/时间(小时)设定。重力滴注按每分钟滴数计:gtt/min = 体积 (mL) × 滴系数 (gtt/mL)/时间 (min)。 滴系数印在输液器包装上:普通输液器为 10、15 或 20 gtt/mL(输血器在美国常为 10 gtt/mL,在英国为 15),微量输液器为 60 gtt/mL。务必使用题目或包装给出的滴系数。
答案: V = 1.3 mL
肝素和胰岛素输注:浓度 = 袋中单位数/袋容量 (units/mL)。泵速 (mL/h) = 每小时单位数/浓度,每小时单位数 = mL/h × 浓度。按体重给药时,先求 units/h = units/kg/h × 体重。推注体积 = 所需单位数/药瓶规格。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: R = 16.5 mL/h
滴定输注:先求以 mcg/mL 计的浓度(mg × 1000/mL)。按体重给药时,mcg/min = mcg/kg/min × 体重。然后 mL/h = mcg/min × 60/浓度。反推时,mcg/kg/min = mL/h × 浓度/(60 × 体重)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: U = 1.97 mL/kg/h
出入量:入量计入所有进入体内的液体(口服液体、静脉输液、静脉用药及冲管液、管饲);冰屑按其体积的一半计。出量计入尿液、引流液、呕吐物和其他丢失。平衡 = 总入量 − 总出量;平衡为负表示净丢失。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: V = 600 mL
输液时间:时间 (h) = 待输体积 (mL)/速率 (mL/h);使用袋中剩余的体积,而不是袋的容量。已输入体积 = 速率 × 时间。把小数小时换算为小时和分钟时,用小数部分 × 60(0.5 h = 30 min,而不是 50 min)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: MFS = 60
Morse 跌倒评分:六个条目。跌倒史:否 0 分,是 25 分。次要诊断:否 0 分,是 15 分。行走辅助:无、卧床休息或护士协助 0 分;拐杖、手杖或助行器 15 分;扶着家具 30 分。静脉输液或封管:否 0 分,是 20 分。步态:正常、卧床休息或轮椅 0 分;虚弱 10 分;受损 20 分。精神状态:了解自身局限 0 分;高估或忘记自身局限 15 分。总分为 0 至 125。各医院的风险分界值不同;常用的一套是 0–24 低风险,25–44 中度风险,45 及以上为高风险。
答案: 低
NEWS2(国家早期预警评分 2,英国皇家内科医师学会 2017):按图表为七个参数分别评分(呼吸频率、量表 1 的 SpO₂、吸空气还是吸氧、收缩压、脉搏、按 ACVPU 量表评定的意识状态和体温),然后把分数相加。临床风险:0–4 为低;任何单项参数得 3 分为中低;5–6 为中;7 或以上为高。总分 5 或以上需要紧急响应。
答案: Osm = 311 mOsm/kg
衍生数值:计算所得的血清渗透压为 2·Na⁺ + 葡萄糖 + 尿素,各值均以 mmol/L 计(葡萄糖和 BUN 以 mg/dL 计时为 2·Na⁺ + 葡萄糖/18 + BUN/2.8);正常约为 275–295 mOsm/kg。P/F 比值是 PaO₂ 除以以小数表示的 FiO₂。海平面的肺泡氧分压为 PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg,A–a 梯度为 PAO₂ − PaO₂。
答案: 适当的代偿
预期代偿:代谢性酸中毒时,温特公式预测 PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg;实测值高于该范围提示合并呼吸性酸中毒,低于该范围提示合并呼吸性碱中毒。阴离子间隙 AG = Na⁺ − (Cl⁻ + HCO₃⁻),正常约为 8–12 mmol/L,用于区分高阴离子间隙与正常阴离子间隙代谢性酸中毒;低白蛋白会掩盖升高的间隙(白蛋白低于 4.0 的部分,每 g/dL 加 2.5)。Δ 比值 (AG − 12)/(24 − HCO₃⁻) 约在 0.8 到 2 之间符合单纯高间隙酸中毒(有些教材用 1 代替 0.8),低于此范围提示合并正常间隙酸中毒,高于 2 提示合并代谢性碱中毒。
答案: 心室率 = 150 bpm
节律标准(II 导联):窦性心律每个 QRS 之前都有直立的 P 波,PR 恒定为 0.12–0.20 s,QRS 狭窄:60–100 次/分为正常窦性心律,低于 60 为窦性心动过缓,高于 100 为窦性心动过速。心房颤动:无 P 波,基线呈颤动,R–R 绝对不规则。心房扑动:约 250–350 次/分的锯齿状扑动波,伴固定的传导比例,如 2:1 或 4:1。一度房室传导阻滞:窦性心律,PR 恒定且大于 0.20 s。交界性心律:窄 QRS,40–60 次/分,P 波缺失或倒置(PR 低于 0.12 s,或 P 波在 QRS 之后)。室性早搏(PVC)是提前出现的宽大(0.12 s 或以上)、形态怪异的 QRS,没有 P 波,T 波方向相反,通常有完全性代偿间歇;二联律是指每隔一个搏动就有一个室性早搏。
答案: 心室率 = 40 bpm
房室传导阻滞:逐个标出 P 波,检查哪些 P 波后面跟着 QRS。一度:每个 P 波都下传,PR 恒定且大于 0.20 s。二度 I 型(Mobitz I,文氏现象):PR 逐搏延长,直到一个 P 波未下传,然后周期重新开始(成组搏动)。二度 II 型(Mobitz II):下传搏动的 PR 保持恒定,P 波突然不下传;QRS 常增宽。三度(完全性)阻滞:P 波和 QRS 波群各自规则但互相独立,PR 随机变化,心房率快于逸搏率(交界性逸搏 40–60 次/分,QRS 窄;室性逸搏 20–40 次/分,QRS 宽)。2:1 阻滞仅凭一份条带无法判断是 I 型还是 II 型。
二度 I 型(文氏现象):每 3 个 QRS 波群对应 4 个 P 波。
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