感染控制与患者安全
方法
- 对每位患者都从标准预防开始:手卫生、针对预期暴露的个人防护装备、安全使用锐器。
- 按传播途径追加预防措施:接触传播(隔离衣、手套)、飞沫传播(外科口罩)、空气传播(N95、负压病房)。
- 保持无菌物品的无菌状态:如有疑问就视为不无菌;更换,绝不擦拭。
- 预防环境中的伤害:防跌倒措施,约束仅作为最后手段,火灾时用 RACE 和 PASS。
- 核对给药的正确原则、两个身份识别信息,以及对高警示药物的额外保障;报告差错和险兆事件。
公式表、每个专题的关键方法步骤和 40 道练习题,完整解答附在最后。
A patient is getting up for the first time after several days in bed. What should the nurse do first?
On the sacrum there is a shallow open area with a pink wound bed and no slough. How is this pressure ulcer classified?
A patient on oxygen is being taken to another department by wheelchair. What should the nurse check first?
While preparing a chemotherapy infusion, the drug splashes onto a nurse’s forearm. What should the nurse do first?
哪项陈述表明对委派中的问责有正确理解?
A child is admitted with a suspected Wilms tumor (nephroblastoma). Which instruction is most important for all staff?
一名患者的 NEWS2 评分升至 7 分。恰当的应对是什么?
一名烧伤面积达体表面积 30% 的患者入院。在最初 24 小时内,最令人担心的早期并发症是什么?
A patient with hyperkalemia is prescribed an oral potassium binder such as patiromer or sodium zirconium cyclosilicate. How does this drug lower potassium?
一名患者的万古霉素谷浓度为 28 mcg/mL;开医嘱者设定的目标为 15–20 mcg/mL。下一次给药时间到了。最好的措施是什么?
A nurse has a needlestick injury from a patient with HIV. When should post-exposure prophylaxis start?
A ventilated ICU patient receives vecuronium, a neuromuscular blocker. Why must sedation and pain relief also be given?
Which ECG finding is typical of atrial flutter?
心肌梗死三周后,一名患者出现发热、胸膜性胸痛(前倾时减轻)和心包摩擦音。最可能的诊断是什么?
A patient with diabetic neuropathy has an ulcer on the ball of the foot. Which measure is most important for healing?
A patient with known back pain says they now cannot feel the skin between their legs and have not passed urine for 12 hours. What should happen?
Which lung problem is a known toxicity of bleomycin?
A patient with gastric outlet obstruction has vomited repeatedly for several days. Which blood picture is most likely?
Which woman on the antenatal unit should the nurse see first?
胎心监护图显示基线变异消失,并反复出现晚期减速。该图形如何分类,需要怎样处理?
How does hydroxyurea (hydroxycarbamide) help children with sickle cell disease?
一名 7 岁儿童在咽痛三周后出现发热、游走性关节痛和新出现的心脏杂音。护士应怀疑什么?
Wernicke 脑病的经典三联征是什么?
The parent of a child recently diagnosed with autism asks, "Did his vaccines cause this?" What is the most accurate response?
练习题(虚构数值,不作为临床指导)。 一位患者的体温为 98.9 °F。用 °C = (°F − 32) × 5/9 把它换算为摄氏度T。取到一位小数。
练习题(虚构数值,不作为临床指导)。 一次维持输液以 100 mL/h 的速度不间断运行。24 小时内输注多少升V?
一名体重 52 kg 的患者体表面积为 1.34 m²。医嘱为 250 mg/m²。求剂量 D,以 mg 表示。
处方剂量为 1740 微克。安瓿浓度为 2 mg/mL。请用 1 mL 注射器抽取剂量:应给多少体积 V?
医嘱要求以 90 mL/h 输液,但没有输液泵。改用滴系数为 10 gtt/mL 的输液器重力滴注。求滴速 R,以每分钟滴数表示。
医嘱要求在 6 小时内输入 500 mL。2 小时后你发现袋中还剩 390 mL,而输液仍须按时完成。 原来的泵速必须提高百分之多少 Δ?
练习题(虚构数值,不作为临床指导)。 一袋中含肝素 25 000 单位,容量 250 mL。医嘱为 14 units/kg/h,患者体重 85 kg。输液泵速率 R 应设为多少 mL/h? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 一名体重 74 kg 的患者的医嘱为nitroglycerin 20 mcg/min。输液袋中含 25 mg,容量 250 mL。求泵速 R,以 mL/h 计。 保留一位小数。
练习题(虚构数值,不作为临床指导)。 记录显示了一名患者在一个 8 小时班次中的出入量。患者体重 104 kg。求平均尿量 U,以 mL/kg/h 计。 保留两位小数。
练习题(虚构数值,不作为临床指导)。 一袋 1000 mL 的液体于 10:30 开始用输液泵以 150 mL/h 输注。到 14:00 时袋中还剩多少 mL V?
练习题(虚构数值,不作为临床指导)。 用 Morse 跌倒评分评估一位练习患者:过去 3 个月内的跌倒史: 否; 次要诊断: 否; 行走辅助: 扶着家具; 静脉输液或封管: 否; 步态: 正常、卧床休息或轮椅; 精神状态: 了解自身局限。求 Morse 总分MFS。
练习题(虚构数值,不作为临床指导)。 对这些观察结果使用 NEWS2 图表(SpO₂ 量表 1):呼吸频率 32 次/分,SpO₂ 98%正在补充吸氧,血压 92/56 mmHg,脉搏 76 次/分,清醒,体温 37.7 °C。患者属于哪个临床风险组?点击它。
练习数值:Na⁺ 131 mmol/L,葡萄糖 11.5 mmol/L,尿素 8.1 mmol/L。计算血清渗透压 Osm = 2·Na⁺ + 葡萄糖 + 尿素,取最接近的整数。
在海平面,某练习血气取自吸入 21% 氧气时,显示 PaO₂ 76 mmHg (10.1 kPa),PaCO₂ 37 mmHg (4.9 kPa)。用 PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 求A–a 梯度。
解读这条 II 导联心律条带。这是什么节律?点击你的答案。
识别这条 II 导联心电图上的节律。点击你的答案。
答案: D · Have the patient sit on the edge of the bed for a short time before standing
After bed rest blood pressure may drop on standing. Sitting on the edge of the bed first, with the feet on the floor, lets the body adjust and lowers the risk of fainting and falls.
答案: C · Category 2
Category 2 (Stage 2 in the US NPIAP system) is partial-thickness skin loss, seen as a shallow open ulcer with a pink-red bed or as a blister. Category 1 is intact skin; categories 3 and 4 are full thickness.
答案: B · That the portable cylinder has enough oxygen for the whole trip
The nurse checks the cylinder gauge and makes sure there is enough oxygen for the trip and possible delays. The cylinder is secured in a holder on the chair, not on the patient’s lap.
答案: A · Remove contaminated PPE and wash the skin with soap and water at once
Skin exposure to hazardous drugs is washed immediately with soap and water after removing contaminated gloves or gown. The exposure is then reported and treated according to policy.
答案: D · “我对决定委派以及跟进结果负有问责。”
委派的护士对委派这一决定以及监督和评价负有问责。被委派者负责在其能力范围内正确地执行任务。
答案: C · Do not palpate the abdomen
Palpating a Wilms tumor can rupture the capsule and spread cancer cells. A sign is often put on the bed to warn staff not to palpate the abdomen.
答案: D · 由具备危重症救治能力的临床团队进行紧急评估
在 NEWS2 中,7 分或以上触发紧急响应,通常需要持续监护,并由有能力处理危重患者的团队紧急评估。
答案: D · 体液丢失引起的低血容量性休克
大面积烧伤使液体移出循环,因此按公式指导的静脉液体复苏和尿量监测是关键。呼吸道烧伤是另一个早期危险。
答案: D · It binds potassium in the gut so it leaves in the stool
Potassium binders exchange potassium in the gut for another ion, so potassium is removed from the body in the stool. They act over hours, so they are not used alone for emergencies; calcium protects the heart, and insulin with glucose shifts potassium into cells quickly.核对依据: High potassium level · MedlinePlus (NIH) (2025)
答案: A · 暂停该剂量,通知开医嘱者并检查肾功能
谷浓度高于目标意味着药物在蓄积,这会增加肾损害的风险。护士应暂停该剂量并通知开医嘱者,后者将调整剂量或间隔。同时检查肾功能。
答案: A · As soon as possible, and within 72 hours at the latest
Post-exposure prophylaxis aims to stop infection becoming established. It works best when started within hours, is not started after 72 hours, and is usually taken for 28 days.
答案: C · Neuromuscular blockers paralyse muscles but do not cause sedation or analgesia
Neuromuscular blockers cause paralysis but leave awareness and pain sensation intact. Without sedation and analgesia, the patient could be awake and in pain while unable to move.
答案: C · Regular sawtooth flutter waves between QRS complexes
Atrial flutter is caused by a re-entry circuit in the right atrium, giving regular sawtooth flutter waves, often at about 300/min with 2:1 block (ventricular rate about 150/min). A chaotic baseline with irregular QRS is atrial fibrillation. Like AF, it carries a stroke risk.
答案: A · 心肌梗死后(Dressler)综合征
Dressler 综合征是心肌梗死数周后发生的免疫介导性心包炎,表现为发热、坐起前倾时缓解的胸膜性疼痛和摩擦音。在再灌注时代现已少见。新的梗死引起的缺血性疼痛不随体位改变,夹层引起放射到背部的撕裂样疼痛。
答案: C · Taking pressure off the ulcer
Offloading (removing pressure) is essential for healing a neuropathic ulcer, along with infection control, good blood supply and specialist foot team care. Hot soaks risk burns because sensation is reduced.
答案: B · Urgent MRI and referral to the spinal surgeons
Saddle anaesthesia with urinary retention suggests cauda equina syndrome. Delay can lead to permanent bladder, bowel and sexual dysfunction. The patient needs an emergency MRI and surgical decompression if confirmed.
答案: A · Pulmonary fibrosis
Bleomycin can cause pneumonitis and pulmonary fibrosis, especially at higher cumulative doses, in older patients and with high oxygen concentrations. Breathlessness or a new cough must be reported.
答案: C · Low chloride, low potassium and metabolic alkalosis
Loss of gastric acid causes a hypochloraemic metabolic alkalosis. Hypokalaemia follows from vomiting and kidney potassium loss as the body tries to save volume. Treatment includes IV saline with potassium.
答案: D · At 34 weeks: severe headache, BP 164/110 mmHg
Severe-range blood pressure with a headache suggests pre-eclampsia with severe features and a risk of eclampsia or stroke. The other women are stable.
答案: A · Ⅲ类:异常图形,需要及时干预并准备尽快分娩
在三级分类系统中,变异消失并伴有反复的晚期或变异减速,或伴有心动过缓,属于Ⅲ类。应立即开始宫内复苏,呼叫团队,如果图形不能缓解则尽快娩出胎儿。
答案: D · It increases fetal haemoglobin, which reduces sickling
Hydroxyurea raises the level of fetal haemoglobin (HbF), which does not sickle, reducing pain crises and acute chest syndrome. Regular blood counts are needed because it can lower white cells and platelets.
答案: A · 急性风湿热
急性风湿热继发于 A 组链球菌咽炎,引起游走性多关节炎、心脏炎、皮疹和舞蹈症。心脏炎可导致风湿性心脏病。治疗链球菌咽痛可预防该病。
答案: C · 意识模糊、共济失调和眼球运动异常
只有部分患者表现出完整的三联征,因此对任何有风险的人都应给予硫胺素。如不治疗,可发展为 Korsakoff 综合征。
答案: C · "Large studies have found no link between vaccines and autism."
Large, well-conducted studies have found no link between vaccines and autism, and the paper that first claimed a link was retracted. Autism is a neurodevelopmental condition with strong genetic contributions.
答案: T = 37.2 °C
温度:°C = (°F − 32) × 5/9,°F = °C × 9/5 + 32。从 °F 换算时先减 32 再乘,从 °C 换算时先乘再加 32。快速核对:37 °C 为 98.6 °F,每 1 °C 相当于 1.8 °F。
答案: V = 2.4 L
量纲分析:先写出已知量,再乘以写成分数形式的换算系数(例如 60 min/1 h 或 1 mg/1000 mcg),使每个不需要的单位在分子和分母各出现一次并相互约去。只剩下所求单位时再计算。使用题目给出的等量关系,只对最终答案取整。
答案: D = 335 mg
Body-surface-area dosing: many cytotoxic and some paediatric doses are prescribed per square metre of body surface area: dose (mg) = dose per m² × BSA (m²). The Mosteller formula estimates BSA = √(height (cm) × weight (kg)/3600).
答案: V = 0.87 mL
抽取剂量:体积 = (处方剂量/药物浓度) × 药物体积。先换算成相同的单位,再检查该体积是否适合注射器,并落在它的某一个刻度上。
答案: R = 15 gtt/min
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
答案: Δ = 17 %
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
许多医院允许在不重开医嘱的情况下进行不超过 25% 的此类调整;请查阅本院规定。
答案: R = 11.9 mL/h
肝素和胰岛素输注:浓度 = 袋中单位数/袋容量 (units/mL)。泵速 (mL/h) = 每小时单位数/浓度,每小时单位数 = mL/h × 浓度。按体重给药时,先求 units/h = units/kg/h × 体重。推注体积 = 所需单位数/药瓶规格。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: R = 12 mL/h
滴定输注:先求以 mcg/mL 计的浓度(mg × 1000/mL)。按体重给药时,mcg/min = mcg/kg/min × 体重。然后 mL/h = mcg/min × 60/浓度。反推时,mcg/kg/min = mL/h × 浓度/(60 × 体重)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
医嘱是针对患者整体的每分钟剂量,所以不需要体重。
答案: U = 0.81 mL/kg/h
出入量:入量计入所有进入体内的液体(口服液体、静脉输液、静脉用药及冲管液、管饲);冰屑按其体积的一半计。出量计入尿液、引流液、呕吐物和其他丢失。平衡 = 总入量 − 总出量;平衡为负表示净丢失。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: V = 475 mL
输液时间:时间 (h) = 待输体积 (mL)/速率 (mL/h);使用袋中剩余的体积,而不是袋的容量。已输入体积 = 速率 × 时间。把小数小时换算为小时和分钟时,用小数部分 × 60(0.5 h = 30 min,而不是 50 min)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: MFS = 30
Morse 跌倒评分:六个条目。跌倒史:否 0 分,是 25 分。次要诊断:否 0 分,是 15 分。行走辅助:无、卧床休息或护士协助 0 分;拐杖、手杖或助行器 15 分;扶着家具 30 分。静脉输液或封管:否 0 分,是 20 分。步态:正常、卧床休息或轮椅 0 分;虚弱 10 分;受损 20 分。精神状态:了解自身局限 0 分;高估或忘记自身局限 15 分。总分为 0 至 125。各医院的风险分界值不同;常用的一套是 0–24 低风险,25–44 中度风险,45 及以上为高风险。
答案: 高
NEWS2(国家早期预警评分 2,英国皇家内科医师学会 2017):按图表为七个参数分别评分(呼吸频率、量表 1 的 SpO₂、吸空气还是吸氧、收缩压、脉搏、按 ACVPU 量表评定的意识状态和体温),然后把分数相加。临床风险:0–4 为低;任何单项参数得 3 分为中低;5–6 为中;7 或以上为高。总分 5 或以上需要紧急响应。
总分 5 或以上需要紧急的临床响应。
答案: Osm = 282 mOsm/kg
衍生数值:计算所得的血清渗透压为 2·Na⁺ + 葡萄糖 + 尿素,各值均以 mmol/L 计(葡萄糖和 BUN 以 mg/dL 计时为 2·Na⁺ + 葡萄糖/18 + BUN/2.8);正常约为 275–295 mOsm/kg。P/F 比值是 PaO₂ 除以以小数表示的 FiO₂。海平面的肺泡氧分压为 PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg,A–a 梯度为 PAO₂ − PaO₂。
答案: A–a 梯度 = 27.48 mmHg
衍生数值:计算所得的血清渗透压为 2·Na⁺ + 葡萄糖 + 尿素,各值均以 mmol/L 计(葡萄糖和 BUN 以 mg/dL 计时为 2·Na⁺ + 葡萄糖/18 + BUN/2.8);正常约为 275–295 mOsm/kg。P/F 比值是 PaO₂ 除以以小数表示的 FiO₂。海平面的肺泡氧分压为 PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg,A–a 梯度为 PAO₂ − PaO₂。
答案: 室上性心动过速(SVT)
节律标准(II 导联):窦性心律每个 QRS 之前都有直立的 P 波,PR 恒定为 0.12–0.20 s,QRS 狭窄:60–100 次/分为正常窦性心律,低于 60 为窦性心动过缓,高于 100 为窦性心动过速。心房颤动:无 P 波,基线呈颤动,R–R 绝对不规则。心房扑动:约 250–350 次/分的锯齿状扑动波,伴固定的传导比例,如 2:1 或 4:1。一度房室传导阻滞:窦性心律,PR 恒定且大于 0.20 s。交界性心律:窄 QRS,40–60 次/分,P 波缺失或倒置(PR 低于 0.12 s,或 P 波在 QRS 之后)。室性早搏(PVC)是提前出现的宽大(0.12 s 或以上)、形态怪异的 QRS,没有 P 波,T 波方向相反,通常有完全性代偿间歇;二联律是指每隔一个搏动就有一个室性早搏。 窄 QRS 心动过速与停顿:室上性心动过速(SVT)是规则的心动过速,约 150–250 次/分钟,QRS 波群较窄;P 波通常看不到,因为它们隐藏在 QRS 波群或 T 波中。成人静息时的窦性心动过速通常低于约 150 次/分钟,且每个 QRS 前都有可见的 P 波;伴 2:1 传导的心房扑动常在约 150 次/分钟,并显示锯齿波。窦性停搏是指窦房结暂时停止发放冲动:出现既无 P 波也无 QRS 的停顿,其长度不是 P–P 周期的整数倍(恰好两个或三个周期的停顿则提示窦房传导阻滞)。
答案: 尖端扭转型室性心动过速
更多室性心律:尖端扭转型室性心动过速是一种多形性室性心动过速,通常为 150–250 次/分钟,其增宽的波群高度不断变化并围绕基线扭转,先向上几个心搏,再向下。教科书将其与 QT 间期延长联系起来,复苏指南中针对它推荐的药物是硫酸镁。室性自搏心律是一种心室逸搏心律:规则、QRS 增宽(0.12 s 或以上)、无 P 波,频率 20–40 次/分钟(加速性室性自搏心律为 40–100 次/分钟)。单形性室速的增宽波群完全相同,频率超过 100 次/分钟。室颤则是混乱的,没有任何重复的波群。
尖端扭转型室性心动过速是与 QT 间期延长相关的多形性 VT。这里只是识别练习。
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