感染控制与患者安全
方法
- 对每位患者都从标准预防开始:手卫生、针对预期暴露的个人防护装备、安全使用锐器。
- 按传播途径追加预防措施:接触传播(隔离衣、手套)、飞沫传播(外科口罩)、空气传播(N95、负压病房)。
- 保持无菌物品的无菌状态:如有疑问就视为不无菌;更换,绝不擦拭。
- 预防环境中的伤害:防跌倒措施,约束仅作为最后手段,火灾时用 RACE 和 PASS。
- 核对给药的正确原则、两个身份识别信息,以及对高警示药物的额外保障;报告差错和险兆事件。
公式表、每个专题的关键方法步骤和 40 道练习题,完整解答附在最后。
A dying patient is no longer drinking and breathes through the mouth. What mouth care is most appropriate?
某患者的氧饱和度目标为 88–92%。哪种疾病最可能解释这个较低的目标?
The laboratory calls with a critical lab result by phone. What should the nurse do?
一名患者正在持续输注高警示药物。交接班时,哪种做法最安全?
The day after a total thyroidectomy, a patient reports tingling around the mouth and in the fingers. What should the nurse do first?
四名患者同时到达急诊科。应先看谁?
A patient says they are "allergic" to codeine because it made them constipated. How should this be recorded?
A nurse is teaching a patient who is starting warfarin. Which statement shows a need for further teaching?
一名患者的左前臂正在输注静脉液体。护士应在何处采集血样?
An 82-year-old woman without a catheter has a urine culture growing bacteria, but no fever, urinary symptoms or change in mental state. What is the best interpretation?
After naloxone reverses an opioid overdose, why must the patient be watched closely?
A patient on digoxin is started on amiodarone. What change should the nurse expect?
Why must inspired air be humidified for a patient with a tracheostomy?
A patient with infective endocarditis is on IV gentamicin with another antibiotic. Which monitoring is most important?
A patient with CKD is booked for a CT scan with iodinated contrast. Which measure helps protect the kidneys?
A patient on carbamazepine is admitted confused, with a sodium of 121 mmol/L. Which explanation is most likely?
What is the main treatment for a venous leg ulcer with an adequate arterial supply?
Why is folinic acid (leucovorin) given after high-dose methotrexate?
A woman at 37 weeks is GBS-positive. When should she receive antibiotics?
硬膜外麻醉后第 1 天,一名女性出现头痛。哪项特征最提示是硬脊膜穿刺后头痛而不是子痫前期?
A 3-day-old has a red, swollen eyelid with a heavy discharge of pus. What should the nurse do?
一名 15 岁女孩要求护士对她的父母保密她的性活动。没有虐待的迹象,也没有严重伤害的风险。最恰当的回应是什么?
Which action reflects trauma-informed care?
A patient who was admitted after a serious suicide attempt says, "I'm angry they saved me. Next time I'll do it properly." What should the nurse do?
练习题(虚构数值,不作为临床指导)。 一次小剂量注射的计算得到 0.73604 mL。 本练习的规则是:低于 1 mL 的体积取到最接近的百分之一 mL。你记录的数值x是多少?
练习题(虚构数值,不作为临床指导)。 一次输注的给药速率为 10 mg/h。请把这个剂量速率D用 mcg/min 表示。取到一位小数。
某患者体重 12 kg,医嘱为单次给药 2 mg/kg。求剂量 D(mg)。
一袋输液在 500 mL 中含 25000 单位药物。医嘱为每小时 500 单位。泵速 R 应设为多少 mL/h?
滴注以 30 gtt/min 的速度通过滴系数为 60 gtt/mL 的输液器。患者在 8 小时内接受多少毫升 V?
一袋中含有 2 g 药物,溶于 500 mL。医嘱为每分钟 1.5 mg。泵速 R 应设为多少 mL/h?
练习题(虚构数值,不作为临床指导)。 一袋中含肝素 20 000 单位,容量 500 mL。医嘱为 18 units/kg/h,患者体重 107 kg。输液泵速率 R 应设为多少 mL/h? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 一名体重 92 kg 的患者的医嘱为norepinephrine 4 mcg/min。输液袋中含 4 mg,容量 250 mL。求泵速 R,以 mL/h 计。 保留一位小数。
练习题(虚构数值,不作为临床指导)。 记录显示了一名患者在一个 8 小时班次中的出入量。患者体重 54 kg。求平均尿量 U,以 mL/kg/h 计。 保留两位小数。
练习题(虚构数值,不作为临床指导)。 一份 500 mL 的输液于 07:30 开始以 150 mL/h 输注。2 小时后速率改为 60 mL/h,之后不再改变。从开始算起多少小时 t 后袋子会输完? 保留一位小数。
练习题(虚构数值,不作为临床指导)。 一位患者的脉搏为 65 次/分,血压为 98/59 mmHg。求休克指数SI = HR/SBP。取到两位小数。
练习题(虚构数值,不作为临床指导)。 用 Morse 跌倒评分评估一位练习患者:过去 3 个月内的跌倒史: 否; 次要诊断: 否; 行走辅助: 无、卧床休息或由护士协助; 静脉输液或封管: 是; 步态: 虚弱; 精神状态: 高估或忘记自身局限。使用分界值 0–24 低,25–44 中度,45 或以上高,点击跌倒风险等级。
练习数值:Na⁺ 129 mmol/L,葡萄糖 16.7 mmol/L,尿素 22.1 mmol/L。计算血清渗透压 Osm = 2·Na⁺ + 葡萄糖 + 尿素,取最接近的整数。
某练习血气显示代谢性酸中毒:pH 7.18,PaCO₂ 36 mmHg (4.8 kPa),HCO₃⁻ 13 mmol/L。把实测的PaCO₂与温特公式比较。点选你的解读。
这条 II 导联心电图条带显示窦性心律伴一次停顿。测量 停顿,即跨越停顿的 R–R 间期,单位为秒。
这条 II 导联心电图显示心房与心室之间存在传导问题。这是什么节律?点击你的答案。
答案: A · Keep the mouth and lips moist with frequent gentle care
Frequent gentle mouth care with moist swabs, water sprays and lip balm keeps the patient comfortable. Forcing fluids risks choking and aspiration.
答案: A · 有高碳酸血症风险的慢阻肺(COPD)
对于有高碳酸性呼吸衰竭风险的慢阻肺患者,给氧过多可能使 CO₂ 升高,因此采用 88–92% 的目标。
答案: B · Write it down, read it back to confirm and report it to the provider promptly
Writing down and reading back critical results confirms they were heard correctly. The nurse then reports them promptly to the responsible provider and documents who was told and when.
答案: B · 两名护士对照处方共同核对输注泵和药袋
交接班时在床边核对,沿管路从药袋追溯到患者,并对照处方核对药物、浓度、剂量和速率,可及早发现编程错误。
答案: D · Check for signs of low calcium and inform the provider
Damage to the parathyroid glands during thyroid surgery can cause hypocalcemia. Tingling, muscle cramps and a positive Chvostek or Trousseau sign need prompt reporting and calcium replacement as prescribed.
答案: A · 一名 2 岁的儿童,流口水,身体前倾,有喘鸣
流口水、前倾(三脚架)姿势和喘鸣提示严重的上气道梗阻,如会厌炎,可能迅速变成完全梗阻。应让孩子保持平静,在气道专家到场之前不要检查咽喉。
答案: A · As a side effect or intolerance, not a true allergy
Constipation is a predictable side effect of opioids, not an immune response. Recording it accurately avoids withholding useful medicines while still noting the patient's experience.
答案: B · "I can take aspirin if I get a headache."
Aspirin and other NSAIDs increase the bleeding risk with warfarin, so patients should ask before taking any new medicine. Paracetamol (acetaminophen) is usually the safer choice for simple pain.
答案: A · 对侧手臂
在正在输液处附近采集的血液会与静脉液体混合,导致葡萄糖偏高或血红蛋白偏低等错误结果。应从另一只手臂采血,如不可能,则按规定处理。
答案: B · Asymptomatic bacteriuria, usually not treated with antibiotics
Asymptomatic bacteriuria is common in older adults and usually should not be treated, because treatment brings adverse effects and resistance without benefit. Exceptions include pregnancy and some urological procedures.核对依据: Asymptomatic Bacteriuria · StatPearls (NCBI Bookshelf) (2023)
答案: D · Naloxone may wear off before the opioid does, so breathing can slow again
Naloxone acts for a shorter time than many opioids, especially long-acting and slow-release ones. Repeated doses or an infusion may be needed.
答案: D · Digoxin levels rise, so the digoxin dose is often reduced
Amiodarone inhibits P-glycoprotein and reduces digoxin clearance, so digoxin levels rise. The digoxin dose is often reduced, and the patient is monitored for bradycardia and toxicity; amiodarone also raises warfarin levels.
答案: A · The nose and upper airway, which warm and moisten air, are bypassed
The tracheostomy bypasses the nose, mouth and pharynx, which warm, filter and humidify air. Without humidification, secretions become thick and can block the tube. Heat and moisture exchangers, humidified oxygen and nebulised saline are used.
答案: A · Drug levels, renal function and hearing or balance changes
Gentamicin is nephrotoxic and ototoxic. Levels are measured to guide dosing, renal function is checked regularly and patients are asked about tinnitus, hearing loss and dizziness. Risk is greater with loop diuretics, older age and longer courses.
答案: D · Good hydration around the scan, often with IV fluids
Iodinated contrast can contribute to AKI in at-risk patients. Good hydration, using the lowest dose needed, avoiding nephrotoxic drugs and checking kidney function afterwards help reduce the risk.
答案: A · Carbamazepine can cause hyponatraemia through an SIADH-like effect
Carbamazepine (and oxcarbazepine) can increase the effect of ADH, leading to water retention and hyponatraemia. Severe hyponatraemia causes confusion and seizures. The drug and sodium need urgent medical review.
答案: B · Compression therapy
Graduated compression reduces venous hypertension and oedema and speeds healing. Leg elevation, exercise and treating the underlying vein disease also help.
答案: B · To rescue normal cells from methotrexate toxicity
Methotrexate inhibits dihydrofolate reductase. Timed folinic acid bypasses this block in normal cells, reducing toxicity such as mucositis and myelosuppression, while methotrexate levels and kidney function are monitored.
答案: C · Intravenously during labour
Oral antibiotics before labour do not prevent recolonisation. IV antibiotics in labour, given ideally at least 4 hours before birth, greatly reduce early-onset GBS disease in the newborn.
答案: A · 坐起时头痛明显加重,平躺时减轻
硬脊膜穿刺后头痛与体位有关,直立时加重,平卧时缓解。高血压、视觉障碍和右上腹痛提示子痫前期,产后也可发生。始终应检测血压。
答案: A · Arrange prompt medical review, as infection from the birth canal is possible
Neonatal conjunctivitis with heavy pus and swelling may be caused by gonococcus or chlamydia acquired during birth. Gonococcal infection can damage the cornea rapidly, so swabs and prompt treatment are needed, and the parents are tested and treated too.
答案: B · 尊重她的保密要求,提供信息,并说明在什么情况下必须分享信息
青少年在法律范围内有权获得保密的医疗服务。护士应说明,如果存在严重伤害的风险,例如虐待或剥削,信息可能会被分享,但不应承诺绝对保密。
答案: C · Explaining each procedure in advance and offering choices wherever possible
Trauma-informed care assumes that many patients have trauma histories. It focuses on safety, trust, choice and collaboration, and on avoiding practices that can re-traumatise, such as unnecessary restraint.
答案: C · Maintain close observation, report the statement and reassess the risk with the team
Anger at surviving and stated future intent show high, ongoing risk. Close observation continues, the team reassesses the risk, and the nurse explores his feelings without judging him.
答案: x = 0.74 mL
取整:看舍入位后面的那个数字:5 或更大则进位,4 或更小则保持原数字不变。只对最终答案取整,绝不对中间步骤取整。典型的考试规则:1 mL 或以上的体积取到十分位,低于 1 mL 的体积取到百分位,滴速取整到整滴,体重取到一位小数;务必遵循题目所规定的规则。
答案: D = 166.7 mcg/min
量纲分析:先写出已知量,再乘以写成分数形式的换算系数(例如 60 min/1 h 或 1 mg/1000 mcg),使每个不需要的单位在分子和分母各出现一次并相互约去。只剩下所求单位时再计算。使用题目给出的等量关系,只对最终答案取整。
答案: D = 24 mg
剂量计算:给药量等于医嘱剂量除以现有药物的规格,再乘以该规格对应的量:给药量 = (医嘱剂量/储备规格) × 储备体积。始终统一单位(先把 g 换成 mg,mg 换成 mcg),并检查答案是否合理。
答案: R = 10 mL/h
剂量计算:给药量等于医嘱剂量除以现有药物的规格,再乘以该规格对应的量:给药量 = (医嘱剂量/储备规格) × 储备体积。始终统一单位(先把 g 换成 mg,mg 换成 mcg),并检查答案是否合理。
答案: V = 240 mL
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
答案: R = 22.5 mL/h
Dose-based infusions: concentration = amount of drug in the bag/bag volume. Pump rate (mL/h) = dose per hour/concentration, and dose per hour = mL/h × concentration. Convert per-minute doses to per-hour (× 60) and keep the mass units the same (1 g = 1000 mg, 1 mg = 1000 mcg).
答案: R = 48.2 mL/h
肝素和胰岛素输注:浓度 = 袋中单位数/袋容量 (units/mL)。泵速 (mL/h) = 每小时单位数/浓度,每小时单位数 = mL/h × 浓度。按体重给药时,先求 units/h = units/kg/h × 体重。推注体积 = 所需单位数/药瓶规格。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: R = 15 mL/h
滴定输注:先求以 mcg/mL 计的浓度(mg × 1000/mL)。按体重给药时,mcg/min = mcg/kg/min × 体重。然后 mL/h = mcg/min × 60/浓度。反推时,mcg/kg/min = mL/h × 浓度/(60 × 体重)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
医嘱是针对患者整体的每分钟剂量,所以不需要体重。
答案: U = 2.2 mL/kg/h
出入量:入量计入所有进入体内的液体(口服液体、静脉输液、静脉用药及冲管液、管饲);冰屑按其体积的一半计。出量计入尿液、引流液、呕吐物和其他丢失。平衡 = 总入量 − 总出量;平衡为负表示净丢失。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
答案: t = 5.3 h
输液时间:时间 (h) = 待输体积 (mL)/速率 (mL/h);使用袋中剩余的体积,而不是袋的容量。已输入体积 = 速率 × 时间。把小数小时换算为小时和分钟时,用小数部分 × 60(0.5 h = 30 min,而不是 50 min)。 这些数字仅供练习;在临床工作中务必遵循当地规程,高危剂量须经双人核对。
约为 5 h 20 min,所以袋子大约在 12:50 输完。
答案: SI = 0.66
血压数值:脉压 PP = SBP − DBP。平均动脉压 MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3,这是基于正常心率下心脏每搏约有三分之二时间处于舒张期的估算(心率快时准确性下降);MAP 至少约 65 mmHg 是常用的器官灌注目标。休克指数 SI = 心率/SBP,正常约为 0.5–0.7;高于约 1 是休克的警示信号。
在通常的 0.5–0.7 之内或之下。
答案: 高风险
Morse 跌倒评分:六个条目。跌倒史:否 0 分,是 25 分。次要诊断:否 0 分,是 15 分。行走辅助:无、卧床休息或护士协助 0 分;拐杖、手杖或助行器 15 分;扶着家具 30 分。静脉输液或封管:否 0 分,是 20 分。步态:正常、卧床休息或轮椅 0 分;虚弱 10 分;受损 20 分。精神状态:了解自身局限 0 分;高估或忘记自身局限 15 分。总分为 0 至 125。各医院的风险分界值不同;常用的一套是 0–24 低风险,25–44 中度风险,45 及以上为高风险。
答案: Osm = 297 mOsm/kg
衍生数值:计算所得的血清渗透压为 2·Na⁺ + 葡萄糖 + 尿素,各值均以 mmol/L 计(葡萄糖和 BUN 以 mg/dL 计时为 2·Na⁺ + 葡萄糖/18 + BUN/2.8);正常约为 275–295 mOsm/kg。P/F 比值是 PaO₂ 除以以小数表示的 FiO₂。海平面的肺泡氧分压为 PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg,A–a 梯度为 PAO₂ − PaO₂。
答案: 合并呼吸性酸中毒
预期代偿:代谢性酸中毒时,温特公式预测 PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg;实测值高于该范围提示合并呼吸性酸中毒,低于该范围提示合并呼吸性碱中毒。阴离子间隙 AG = Na⁺ − (Cl⁻ + HCO₃⁻),正常约为 8–12 mmol/L,用于区分高阴离子间隙与正常阴离子间隙代谢性酸中毒;低白蛋白会掩盖升高的间隙(白蛋白低于 4.0 的部分,每 g/dL 加 2.5)。Δ 比值 (AG − 12)/(24 − HCO₃⁻) 约在 0.8 到 2 之间符合单纯高间隙酸中毒(有些教材用 1 代替 0.8),低于此范围提示合并正常间隙酸中毒,高于 2 提示合并代谢性碱中毒。
答案: 停顿 = 1.8 s
窄 QRS 心动过速与停顿:室上性心动过速(SVT)是规则的心动过速,约 150–250 次/分钟,QRS 波群较窄;P 波通常看不到,因为它们隐藏在 QRS 波群或 T 波中。成人静息时的窦性心动过速通常低于约 150 次/分钟,且每个 QRS 前都有可见的 P 波;伴 2:1 传导的心房扑动常在约 150 次/分钟,并显示锯齿波。窦性停搏是指窦房结暂时停止发放冲动:出现既无 P 波也无 QRS 的停顿,其长度不是 P–P 周期的整数倍(恰好两个或三个周期的停顿则提示窦房传导阻滞)。
停顿中没有出现 P 波,且停顿不是 P–P 周期的整数倍:窦性停搏。恰好两个或三个周期的停顿则提示窦房传导阻滞。
答案: 二度 I 型房室传导阻滞(文氏现象)
房室传导阻滞:逐个标出 P 波,检查哪些 P 波后面跟着 QRS。一度:每个 P 波都下传,PR 恒定且大于 0.20 s。二度 I 型(Mobitz I,文氏现象):PR 逐搏延长,直到一个 P 波未下传,然后周期重新开始(成组搏动)。二度 II 型(Mobitz II):下传搏动的 PR 保持恒定,P 波突然不下传;QRS 常增宽。三度(完全性)阻滞:P 波和 QRS 波群各自规则但互相独立,PR 随机变化,心房率快于逸搏率(交界性逸搏 40–60 次/分,QRS 窄;室性逸搏 20–40 次/分,QRS 宽)。2:1 阻滞仅凭一份条带无法判断是 I 型还是 II 型。
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