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Nama: ____________________ Tanggal: ____________
1.Mudah
Mannitol is an osmotic diuretic used mainly to:
ATreat high blood pressure long term
BRaise serum potassium
CPrevent blood clots
DReduce raised intracranial pressure
2.Mudah
How long does it usually take for an SSRI to improve mood noticeably?
AA few hours
BSeveral weeks
COne or two days
DAbout six months
3.Mudah
Timolol eye drops are used mainly to treat:
AGlaucoma
BBacterial conjunctivitis
CDry eyes
DCataracts
4.Sedang
Kombinasi SSRI dengan obat mana yang paling meningkatkan risiko sindrom serotonin?
AOmeprazol
BPenghambat monoamin oksidase
CAmoksisilin
DParasetamol
5.Sedang
A patient has oral mucositis after chemotherapy. Which advice is appropriate?
ABrush hard with a firm toothbrush to remove debris
BUse an alcohol-based mouthwash several times a day to kill germs
CUse a soft toothbrush and rinse with saline or a bland mouthwash
DEat spicy and acidic foods to stimulate healing
6.Sedang
Which assessment is most important during IV mannitol therapy?
ABlood glucose before meals and signs of hypoglycaemia
BLiver enzymes and signs of jaundice
CUrine output, electrolytes and signs of fluid overload
DPlatelet count and signs of bleeding
7.Sulit
Why is the TPMT enzyme often tested before azathioprine is started?
ATPMT testing shows whether the patient has tuberculosis
BHigh TPMT activity causes an allergic reaction to azathioprine
CTPMT is needed to absorb azathioprine from the gut
DLow TPMT activity causes toxic levels and marrow suppression
8.Sulit
Bayi baru lahir yang diberi kloramfenikol dapat mengalami "grey baby syndrome". Apa alasan utamanya?
AGinjal bayi baru lahir mengekskresikan obat terlalu cepat, sehingga diberikan dosis lebih tinggi
BGlukuronidasi di hati yang belum matang membuat obat terakumulasi
CBayi baru lahir membentuk antibodi terhadap obat
DKloramfenikol diubah menjadi vitamin K pada neonatus
Kunci jawaban
1. D · Reduce raised intracranial pressure
2. B · Several weeks
3. A · Glaucoma
4. B · Penghambat monoamin oksidase
5. C · Use a soft toothbrush and rinse with saline or a bland mouthwash
6. C · Urine output, electrolytes and signs of fluid overload
7. D · Low TPMT activity causes toxic levels and marrow suppression
8. B · Glukuronidasi di hati yang belum matang membuat obat terakumulasi
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