Lembar kerja Farmakologi dengan jawaban

How is pernicious anaemia usually treated?

1. AWith oral iron tablets for three months, then stopping
2. BWith vitamin B12 injections, usually for life
3. CWith blood transfusions every month
4. DWith folic acid alone

Which harmless effect of rifampicin should patients be warned about?

1. AWhite spots on the teeth
2. BOrange-red colouring of urine, sweat and tears
3. CGreen colouring of the stools
4. DBlue colouring of the fingernails and lips

Which vasopressor is usually first-line for septic shock that persists after fluids?

1. ANoradrenaline (norepinephrine)
2. BIsoprenaline (isoproterenol)
3. CAdenosine
4. DGlyceryl trinitrate

Why are patients taking simvastatin often advised to avoid large amounts of grapefruit juice?

1. AGrapefruit makes the tablet dissolve in the mouth
2. BGrapefruit blocks cholesterol absorption and causes low cholesterol
3. CGrapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
4. DGrapefruit speeds up simvastatin breakdown in the liver, so the drug stops working

Why is testing for HLA-B*15:02 recommended before carbamazepine in people of some Asian ancestries?

1. AIt greatly raises the risk of Stevens–Johnson syndrome
2. BThis gene variant causes carbamazepine to raise blood glucose
3. CThis gene variant speeds up the kidney excretion of carbamazepine
4. DThis gene variant makes carbamazepine ineffective

A patient starting sulfasalazine should be told about which harmless effect?

1. AWhite spots on the nails
2. BOrange-yellow colouring of the urine
3. CGreen colouring of the sweat
4. DBlue colouring of the tongue and gums

A toddler swallowed many of his mother's iron tablets. He has vomiting and bloody diarrhoea. Which drug may be used to bind iron?

1. ADeferoxamine (desferrioxamine)
2. BAcetylcysteine
3. CNaloxone
4. DActivated charcoal given by mouth

Probenesid pernah digunakan untuk menaikkan kadar penisilin plasma. Bagaimana caranya?

1. AProbenesid menghambat metabolisme penisilin di hati
2. BProbenesid menggeser penisilin dari protein plasma
3. CProbenesid meningkatkan penyerapan penisilin dari usus halus
4. DProbenesid memblokir sekresi tubulus penisilin di ginjal