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Nama: ____________________ Tanggal: ____________
1.Mudah
Which adverse effect can follow long-term use of strong topical corticosteroids?
AThickening of the skin
BPermanent darkening of the nails
CThinning of the skin
DIncreased hair loss on the scalp
2.Mudah
What is drug synergism?
ATwo drugs together produce exactly the sum of their separate effects
BTwo drugs together have a greater effect than the sum of each alone
COne drug cancels out the effect of another drug
DA drug loses its effect after repeated doses
3.Mudah
Apa yang digambarkan oleh "potensi" suatu obat?
ABerapa lama obat bertahan di dalam tubuh
BEfek terbesar yang dapat dihasilkan obat
CSeberapa aman obat dibandingkan obat lain dalam kelasnya
DJumlah obat yang diperlukan untuk menghasilkan efek tertentu
4.Sedang
Which drug is used for torsades de pointes?
AIntravenous magnesium sulfate
BIntravenous verapamil
COral digoxin
DIntravenous adenosine (rapid push)
5.Sedang
Efek samping mana yang khas untuk metoklopramid, terutama pada orang muda?
AGlukosa darah rendah
BGangguan gerak ekstrapiramidal seperti distonia akut
CKonstipasi berat
DBatuk kering
6.Sedang
A patient with Addison's disease on hydrocortisone develops a fever with flu. What is the usual advice?
AIncrease the dose as instructed (sick-day rules) and seek help if vomiting
BStop the hydrocortisone until the fever settles, to let the body recover
CHalve the hydrocortisone to reduce side effects
DMake no change, as illness does not affect cortisol needs
7.Sulit
An older patient with coronary artery disease is starting levothyroxine for hypothyroidism. Why is a low starting dose used?
AHigh starting doses cause permanent hypothyroidism
BLevothyroxine causes severe hypoglycaemia in older patients
COlder patients absorb levothyroxine much better, so small doses are all they need
DFast replacement raises cardiac oxygen demand and can cause angina
8.Sulit
Which regimen is standard for eradicating Helicobacter pylori?
AA single dose of an antibiotic given intravenously
BAn H2 blocker taken only when pain occurs
CAcid suppression plus at least two antibiotics, often with bismuth, for 14 days
DAn antacid alone, taken after meals and at bedtime for six months
Kunci jawaban
1. C · Thinning of the skin
2. B · Two drugs together have a greater effect than the sum of each alone
3. D · Jumlah obat yang diperlukan untuk menghasilkan efek tertentu
4. A · Intravenous magnesium sulfate
5. B · Gangguan gerak ekstrapiramidal seperti distonia akut
6. A · Increase the dose as instructed (sick-day rules) and seek help if vomiting
7. D · Fast replacement raises cardiac oxygen demand and can cause angina
8. C · Acid suppression plus at least two antibiotics, often with bismuth, for 14 days
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