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Nama: ____________________ Tanggal: ____________
1.Mudah
Which herbal product is commonly taken for sleep and can add to the effect of sedatives?
APeppermint
BGinger
CValerian
DCranberry
2.Mudah
Manakah yang merupakan reaksi fase II (konjugasi) yang khas dalam metabolisme obat?
AHidrolisis
BReduksi
COksidasi
DGlukuronidasi
3.Mudah
Fibrates such as fenofibrate mainly lower which blood lipid?
ATriglycerides
BHDL cholesterol
CBile acids
DLipoprotein(a) only
4.Sedang
Why is IV promethazine given with great caution?
AIt is a strong opioid that causes addiction
BIt causes immediate kidney failure
CIt can cause severe tissue injury if it leaks or enters an artery
DIt causes a severe rise in blood pressure when it is given intravenously
5.Sedang
Before starting a TNF-alpha inhibitor such as adalimumab, which test is required?
AA bone density scan
BAn echocardiogram in every patient
CScreening for latent tuberculosis
DA glucose tolerance test
6.Sedang
A patient must mix regular (soluble) insulin and NPH (isophane) insulin in one syringe. What is the correct order?
ADraw them up in separate syringes, then mix them in a cup
BShake both vials hard, then draw them up in any order
CDraw up the cloudy NPH insulin first, then the clear regular insulin
DDraw up the clear regular insulin first, then the cloudy NPH insulin
7.Sulit
Dosis intravena 500 mg menghasilkan konsentrasi plasma awal 10 mg/L. Berapa volume distribusinya?
A5000 L
B5 L
C50 L
D500 L
8.Sulit
A patient with severe liver cirrhosis takes oral propranolol, a drug with a high first-pass metabolism. What effect is expected?
AThe first-pass effect increases, so the drug becomes inactive
BLess drug is absorbed from the gut, so a higher dose is needed
CMore drug reaches the circulation, so a lower dose may be needed
DThe drug is excreted faster by the kidney, so it works for a shorter time
Kunci jawaban
1. C · Valerian
2. D · Glukuronidasi
3. A · Triglycerides
4. C · It can cause severe tissue injury if it leaks or enters an artery
5. C · Screening for latent tuberculosis
6. D · Draw up the clear regular insulin first, then the cloudy NPH insulin
7. C · 50 L
8. C · More drug reaches the circulation, so a lower dose may be needed
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