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Nama: ____________________ Tanggal: ____________
1.Mudah
What is drug synergism?
ATwo drugs together produce exactly the sum of their separate effects
BA drug loses its effect after repeated doses
COne drug cancels out the effect of another drug
DTwo drugs together have a greater effect than the sum of each alone
2.Mudah
Organ mana yang mengekskresikan sebagian besar obat larut air dan metabolitnya?
AKulit
BGinjal
CHati
DParu-paru
3.Mudah
Buspirone is used mainly to treat:
AAcute alcohol withdrawal
BGeneralised anxiety disorder
CSevere pain
DPanic attacks needing immediate relief
4.Sedang
Digoxin 0,25 mg is ordered. The tablets available are 0,125 mg. How many tablets should be given?
A4 tablets
B1 tablet
C0,5 tablet
D2 tablets
5.Sedang
A patient must mix regular (soluble) insulin and NPH (isophane) insulin in one syringe. What is the correct order?
ADraw up the cloudy NPH insulin first, then the clear regular insulin
BShake both vials hard, then draw them up in any order
CDraw up the clear regular insulin first, then the cloudy NPH insulin
DDraw them up in separate syringes, then mix them in a cup
6.Sedang
Why are patients taking simvastatin often advised to avoid large amounts of grapefruit juice?
AGrapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
BGrapefruit speeds up simvastatin breakdown in the liver, so the drug stops working
CGrapefruit blocks cholesterol absorption and causes low cholesterol
DGrapefruit makes the tablet dissolve in the mouth
7.Sulit
Why are tetracyclines usually avoided in pregnancy and in young children (under 8 years in US guidance, under 12 years in the UK)?
AThey cause grey baby syndrome in infants
BThey bind to growing teeth and bone and stain the teeth permanently
CThey cause severe hearing loss in children
DThey block the action of growth hormone and stunt the child's growth
8.Sulit
A man on long-term testosterone therapy has a rising haematocrit. Why is this important?
ATestosterone raises red cell production, increasing clot risk
BIt is a sign of liver failure caused by testosterone
CIt means the testosterone dose is too low
DA high haematocrit shows that the testosterone is not being absorbed
Kunci jawaban
1. D · Two drugs together have a greater effect than the sum of each alone
2. B · Ginjal
3. B · Generalised anxiety disorder
4. D · 2 tablets
5. C · Draw up the clear regular insulin first, then the cloudy NPH insulin
6. A · Grapefruit inhibits CYP3A4 in the gut, raising simvastatin levels and myopathy risk
7. B · They bind to growing teeth and bone and stain the teeth permanently
8. A · Testosterone raises red cell production, increasing clot risk
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