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Nama: ____________________ Tanggal: ____________
1.Mudah
Drugs whose names end in "-sartan", such as losartan, belong to which class?
AAlpha-1 blockers
BAngiotensin II receptor blockers
CLoop diuretics
DACE inhibitors, which block the converting enzyme
2.Mudah
Which of these is a second-generation (atypical) antipsychotic?
AHaloperidol
BChlorpromazine
CFluphenazine
DOlanzapine
3.Mudah
What is drug synergism?
AOne drug cancels out the effect of another drug
BTwo drugs together have a greater effect than the sum of each alone
CA drug loses its effect after repeated doses
DTwo drugs together produce exactly the sum of their separate effects
4.Sedang
How should a patient take oral alendronate?
AWith breakfast and coffee to protect the stomach
BCrushed into yoghurt with calcium supplements
CWith milk at bedtime, then lying down straight away to aid absorption
DWith plain water on an empty stomach, staying upright for 30 minutes
5.Sedang
Which adverse effect of doxorubicin requires monitoring of heart function?
ACumulative heart muscle damage leading to heart failure
BSevere hypertension during the infusion itself
CRapid rise in cholesterol
DPericarditis caused by infection
6.Sedang
Agonis parsial diberikan bersama agonis penuh dosis tinggi. Apa yang terjadi pada responsnya?
ARespons berlipat dua, karena kedua obat mengaktifkan reseptor
BRespons tetap persis sama seperti pada dosis tinggi agonis penuh saja
CRespons turun, karena agonis parsial bersaing memperebutkan reseptor
DRespons naik melebihi maksimum agonis penuh
7.Sulit
A patient taking dabigatran has a life-threatening bleed. Which specific reversal agent is used?
AIdarucizumab
BVitamin K
CProtamine sulfate
DAndexanet alfa
8.Sulit
Seorang pasien dengan overdosis aspirin (salisilat) tahap awal mengalami tinitus dan bernapas cepat. Pola asam–basa mana yang klasik?
AAlkalosis respiratorik yang diikuti asidosis metabolik
BAsidosis respiratorik dengan bikarbonat normal
CAlkalosis metabolik murni
DAlkalosis metabolik yang diikuti asidosis respiratorik
Kunci jawaban
1. B · Angiotensin II receptor blockers
2. D · Olanzapine
3. B · Two drugs together have a greater effect than the sum of each alone
4. D · With plain water on an empty stomach, staying upright for 30 minutes
5. A · Cumulative heart muscle damage leading to heart failure
6. C · Respons turun, karena agonis parsial bersaing memperebutkan reseptor
7. A · Idarucizumab
8. A · Alkalosis respiratorik yang diikuti asidosis metabolik
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