1.やさしい
治療係数(治療指数)とは何ですか?
- A経口投与量のうち体循環に届く割合
- B定常状態に達するまでの時間
- C中毒量と有効量の比
- D1 日の投与回数
2.やさしい
Which opioid receptor is mainly responsible for the pain relief and respiratory depression of morphine?
- AMu receptor
- BKappa receptor
- CDelta receptor
- DNicotinic receptor
3.やさしい
Tamoxifen is used mainly to treat:
- AProstate enlargement and prostate cancer in older men
- BType 2 diabetes
- COestrogen receptor-positive breast cancer
- DOsteoarthritis
4.ふつう
A patient given haloperidol develops a sudden painful twisting of the neck and the eyes roll upward. Which drug is usually given?
- AAn anticholinergic such as benzatropine (benztropine)
- BNaloxone
- CA second dose of haloperidol
- DDantrolene by mouth to relax the twisted neck muscles
5.ふつう
How many micrograms are in 0.5 mg?
- A5 micrograms
- B500 micrograms
- C50 micrograms
- D5000 micrograms
6.ふつう
血漿中の薬のうち、受容体に届いて効果を生めるのはどの分画ですか?
- A結合していない(遊離)分画
- B赤血球に貯蔵された分画
- Cアルブミンに結合した分画
- Dグロブリンに結合した分画
7.むずかしい
A patient on disulfiram becomes flushed, nauseated and has palpitations after using a mouthwash. What is the most likely cause?
- ADisulfiram toxicity from taking too many tablets by mistake
- BLow blood glucose from skipping breakfast
- CAlcohol in the mouthwash caused a disulfiram–alcohol reaction
- DAn allergy to mint flavouring in the mouthwash
8.むずかしい
A nurse calculates a child's dose and finds it is ten times higher than the usual range in the drug reference. What should the nurse do?
- AGive the dose, because the prescriber is responsible for the order
- BGive half the dose as a compromise
- CWithhold it, recheck the calculation and clarify with the prescriber
- DGive one tenth of the dose without telling anyone
解答
- 1. C · 中毒量と有効量の比
- 2. A · Mu receptor
- 3. C · Oestrogen receptor-positive breast cancer
- 4. A · An anticholinergic such as benzatropine (benztropine)
- 5. B · 500 micrograms
- 6. A · 結合していない(遊離)分画
- 7. C · Alcohol in the mouthwash caused a disulfiram–alcohol reaction
- 8. C · Withhold it, recheck the calculation and clarify with the prescriber
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