解答つき薬理学ワークシート

Lithium is used mainly to treat which condition?

1. AGeneralised anxiety disorder
2. BSchizophrenia with no mood symptoms
3. CBipolar disorder
4. DAttention deficit hyperactivity disorder

抗うつ薬のセルトラリンは、シナプスのどの神経伝達物質の濃度を高めますか？

1. Aアセチルコリン
2. Bドパミン
3. Cセロトニン
4. DGABA

How does tramadol relieve pain?

1. AWeak opioid agonism plus inhibiting the reuptake of serotonin and noradrenaline
2. BAntagonising NMDA receptors in the spinal cord and blocking sodium channels
3. CBlocking COX enzymes in the periphery
4. DBlocking sodium channels in peripheral nerves

ヘパリンはどのようにして抗凝固作用を生みますか？

1. Aアンチトロンビンを増強し、トロンビンと第 Xa 因子を不活化させる
2. Bすでにある血栓のフィブリンを分解する
3. C血小板の COX-1 を不可逆的に阻害する
4. D肝臓でのビタミン K 依存性凝固因子の合成を遮断する

How does sucralfate help a peptic ulcer heal?

1. AIt kills Helicobacter pylori directly
2. BIt neutralises acid by releasing bicarbonate
3. CIt blocks histamine H2 receptors in the stomach
4. DIt forms a protective coating over the ulcer base

After several years of levodopa treatment, which problem is common?

1. ADyskinesias and "on–off" fluctuations in response
2. BSevere hypoglycaemia after each dose
3. CPermanent hearing loss
4. DComplete and permanent loss of all Parkinson's symptoms

ある薬の分布容積は 40 L で、バイオアベイラビリティは完全です。目標血漿濃度 2 mg/L を得る負荷量はどれですか？

1. A160 mg
2. B42 mg
3. C80 mg
4. D20 mg

A nurse calculates a child's dose and finds it is ten times higher than the usual range in the drug reference. What should the nurse do?

1. AWithhold it, recheck the calculation and clarify with the prescriber
2. BGive half the dose as a compromise
3. CGive one tenth of the dose without telling anyone
4. DGive the dose, because the prescriber is responsible for the order